结直肠息肉发病危险因素分析  

Analysis on risk factors of colorectal polyps

作　　者：李艳萍[1] 李骥[1] 盖小荣[2] 吴军[3] 李文彬[1] 吴东[1] 姚方[1] 李景南[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院消化内科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院体检中心,北京100730 [3]山东省东营市胜利油田中心医院消化内科,山东东营257034

出　　处：《首都医科大学学报》2013年第5期684-688,共5页Journal of Capital Medical University

基　　金：首都卫生发展科研专项(首发2011-4001-01)~~

摘　　要：目的 探讨与结直肠息肉发病相关的危险因素.方法 回顾性病例对照研究,选取在北京协和医院内镜中心行结肠镜检查发现结直肠息肉的病例,以健康体检人群行结肠镜未发现异常的病例为对照,给予问卷调查相关高危因素及分析息肉内镜下表现,采用SAS 9.2软件对数据进行统计学分析.结果 本研究共纳入结直肠息肉患者106例,正常对照组383例.多因素Logistic回归分析年龄（OR=1.343,95% CI：1.063~1.697）、癌症家族史（OR=3.013,95%CI：1.675~5.419）、摄食红肉（OR=1.650,95%CI：1.085~2.509）是发病的独立危险因素.息肉患者中,男性息肉瘤性检出率高于女性（P〈0.05）,随着年龄增大,腺瘤性息肉发生率显著增加（P〈0.05）.结论 年龄、癌症家族史、红肉摄入比例高是结直肠息肉发生的危险因素,摄入新鲜水果蔬菜为保护性因素.老年男性患者息肉瘤性率增加.通过高危因素问卷调查,有助于有针对性地开展结直肠肿瘤筛查.Objective To investigate the risk factors that may be associated with colorectal polyps. Methods Patients who underwent complete colonoseopy at Peking Union Medical College Hospital endoscopy center between June 1, 2012 and May 31, 2013 were enrolled into this study. These patients were divided into polyps group and normal control group. Each case undertook the same questionnaire about their general situation and endoscopic polyps performance. The data were statistically analyzed by using SAS 9.2. Results Totally 106 eolorectal polyps patients were enrolled into the polyps group and 383 normal persons were enrolled into control group. Multivariate logistic regression analyses were performed. Age （ OR = 1. 343, 95% CI： 1. 063 - 1. 697 ）, family history of cancer （ OR = 3.013,95 % CI： 1. 675 - 5.419 ） and high proportion of red meat intake （ OR = 1. 650, 95 % CI： 1. 085 - 2. 509 ） were independent risk factors for colorectal polyps. Adenomatous polyps was easier to be detected in male than in female （ P 〈 0. 05 ） and the proportion of patients with adenomatous polyps increased with age （ P 〈 0. 05 ）. Conclusion Age, family history of cancer and high proportion of red meat intake are independent risk factors for colorectal polyps, while high proportion of fresh fruits and vegetables intake are protective factors. Elderly male patients may have increase risk to occur adenomatous polyps. Risk factors questionnaire is useful in screening for coloreetal tumors.

关 键 词：结直肠息肉 结直肠癌 危险因素 筛查 

分 类 号：R574.6[医药卫生—消化系统]