血清同型半胱氨酸与卒中后抑郁的关系  

Correlation of serum homocysteine and post stroke depression

作　　者：高琳[1] 于明[1] 陈慧娟[1] 过红明[1] 张晓林[1] 吴旭明[1] 徐建慧[1] 

机构地区：[1]江苏大学附属医院神经内科,212001

出　　处：《江苏医药》2013年第20期2409-2411,共3页Jiangsu Medical Journal

基　　金：江苏大学医学临床科技发展基金(JLY2010123)

摘　　要：目的探讨血清同型半胱氨酸(Hcy)与卒中后抑郁的关系。方法急性脑卒中患者85例,根据血清Hcy水平分为两组:Hcy>15μmol/L为A组(40例);Hcy≤15μmol/L为B组(45例)。比较两组患者卒中后抑郁的发生率、抑郁自评量表(SDS)评分、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)及血清脑源性神经营养因子(BDNF)水平。结果 A组抑郁症的发病率高于B组(50.0%vs.28.9%)(P<0.05);A组SDS评分高(P<0.05);A组血清BDNF浓度较B组低[(831.7±289.0)pg/ml vs.(1276.6±277.9)pg/ml](P<0.05)。结论高Hcy血症患者卒中后抑郁发生的比例较高,且程度严重;BDNF可能参与了高Hcy血症的病理生理作用。Objective To investigate the correlation between serum homocysteine （Hcy） and post stroke depression （PSI））. Methods A total of 85 patients with acute stroke was divided into group A（serum Hcy〉 15 μmol/L, 40 cases） and group B（serum Hcy≤15 μmol/L, 45 cases）. The incidence of PSI：）, scores of self-rating depression scale（SDS） and National Institutes of Health Stroke Scale（NIHSS）, Barthel index（BI）, serum level of brain-derived neurotrophic factor（BDNF） were compared between two groups. Results The incidence of PSD in group A was higher than that in group B（50. 0% vs. 28. 9%）（P〈0. 05）. The score of SDS in group A was higher than that in group B（P〈0. 05）. Serum level of BDNF in group A was lower than that in group B[（831.7±289. 0） pg/ml vs. （1276. 6±277.9） pg/ml]（P〈0.05）. Conclusion The stroke patients with hyperhomocysteinemia has a higher incidence and more severity of PSI）. BDNF may take a role in the pathophysiology of hyperhomo-cysteinemia.

关 键 词：同型半胱氨酸 卒中 抑郁 脑源性神经营养因子 

分 类 号：R743[医药卫生—神经病学与精神病学]