蛋白酪氨酸磷酸酶1B在非小细胞肺癌组织中的表达及其与预后的关系  

Expression of protein-tyrosine-phosphatase 1B in non-small-cell lung cancer and its prognostic significance

作　　者：王兆峰[1] 刘红兵[1] 姚艳雯[1] 陈芳芳[1] 宋勇[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院呼吸内科,210002

出　　处：《中华医学杂志》2013年第38期3027-3030,共4页National Medical Journal of China

基　　金：江苏省自然科学基金（BK2011658）

摘　　要：目的探讨蛋白酪氨酸磷酸酶1B（胛P1B）在非小细胞肺癌（NSCLC）组织中的表达及其对预后的预测价值。方法运用免疫组织化学EnVision法，检测2000年6月至2006年10月南京军区南京总医院手术切除的经常规病理证实的63例NSCLC肺癌组织和9例肺炎组织中门P1B的表达并进行统计学分析，探讨其与临床病理特征和预后的关系。结果胛P1B在肺炎组织中均为阴性表达，在NSCLC组织中的表达阳性率为50．8％（32／63），显著高于肺炎组（χ2。=8．229，P=0．004）；胛P1B在NSCLC组织中的表达与性别、年龄、吸烟、肿瘤大小、病理类型、淋巴结转移及化疗与否无明显相关，而与pTNM分期显著相关（χ2=6．426，P=0．040）。Kaplan．Meire生存分析显示，胛P1B表达与肺癌患者的总生存期明显相关（Logrank，P=0．047）。多因素Cox回归分析显示门P1B的表达是影响NSCLC预后的独立因素（HR=2．050，P=0．044），pTNM分期也是影响NSCLC独立预后因素（HR=3．631，P=0．000）。结论PTP1B在肺癌发生发展中起重要的作用，PTP1B及pTNM分期是NSCLC独立的预后因素。Objective To explore the protein-tyrosine-phosphatase 1B （PTP1 B） expression and its prognostic significance in non-small-cell lung cancer （NSCLC）. Methods Immunohistochemical method of EnVision was applied to investigate the expression of PTP1B in lung specimens from 63 cases with NSCLC and 9 cases with pneumonia confirmed by pathological examination after surgical removals at Jinling Hospital from June 2000 to October 2010. The data of PTP1B expression in different lung tissues and its relationship with clinicopathologieal features and prognostic value for survival were analyzed by ehi-square test, Kaplan- Meire survival analysis, Log rank test and muhivariable Cox regression analysis. Results The expression of PTP1B was negative in pneumonia group while positive in NSCLC tissues （32/63, 50. 8% ） （ χ2 = 8. 229, P =0. 004）. The expression of PTP1B in NSCLC tissue was not correlated with gender, age, smoking history, tumor size, pathological type, lymph node metastasis and chemotherapy, but significantly associated with pTNM staging （ χ2 = 6. 426, P = 0. 040）. Kaplan-Meire survival analysis showed that the expression of PTP1B was significantly correlated with overall survival （Log-rank, P = 0. 047 ）. Muhivariable Cox regression analysis indicated that both PTP1B （HR =2. 050, P =0. 044） and pTNM staging （HR =3. 631, P = 0. 000） were independent prognostic factors for NSCLC. Conclusions PTP1B may be a biomarker for differential diagnosis of malignant lung disease. And PTP1B and pTNM were independent prognostic factors for NSCLC.

关 键 词：癌  非小细胞肺 蛋白质酪氨酸磷酸酶 预后 

分 类 号：R734.2[医药卫生—肿瘤]