神经干细胞移植与脑梗死  

Neural stem cell transplantation and cerebral infarction

作　　者：李通[1] 刘畅[1] 寇雨霏[1] 段伟[1] 罗德欣[1] 

机构地区：[1]哈尔滨医科大学附属第五医院神经内科,黑龙江省大庆市163319

出　　处：《中国组织工程研究》2013年第40期7175-7180,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:将神经干细胞移植到脑梗死病灶区可以促进受损神经细胞的修复。目的:分析神经干细胞移植治疗脑梗死的相关影响因素。方法:文章通过数据库检索的方式分析近年来关于神经干细胞移植治疗脑梗死的实验研究,从中国临床试验注册和基础实验研究两方面分析神经干细胞与脑梗死的研究进展。结果与结论:脑梗死后神经干细胞的增殖和分化与脑内微环境密切相关,梗死区域有大量的神经细胞丢失。细胞因子在神经干细胞移植修复神经功能损伤时发挥一定作用,能够诱导大鼠脑梗死后神经干细胞的增殖、分化和迁移,目前被证实的有表皮生长因子、脑源性神经营养因子、胰岛素样生长因子1、神经生长因子、碱性成纤维细胞生长因子等。针灸和中医药对脑梗死后室管膜下区神经干细胞的增殖、迁移和分化有促进作用。神经干细胞移植治疗脑梗死的研究已经取得了阶段性进展,未来仍有许多问题需要进一步解决。BACKGROUND： Neural stem cells transplanted into the infarct region can promote the recovery of damaged nerve cells after cerebral infarction. OBJECTIVE： To analyze the relevant influential factors of neural stem cell transplantation in the treatment of cerebral infarction. METHODS： In this paper, we analyzed the experimental studies concerning neural stem cell transplantation for cerebral infarction published in recent years based on database search. There were main two aspects for discussing the progress in neural stem cells and cerebral infarction, the Chinese clinical trial registration and basic experimental studies. RESULTS AND CONCLUSION： After cerebral infarction, neural stem cell proliferation and differentiation is closely related to the brain microenvironment. Large amount of nerve cell loss can be found in the infarct region Cytokines can play a role in the neural stem cell transplantation to repair neurological injury after cerebral infarction, and also can induce neural stem cell proliferation, differentiation and migratiOn, including epidermal growth factor, brain-derived neurotrophic factor, insulin-like growth factor 1, nerve growth factor, and basic flbroblast growth factor. Acupuncture and traditional Chinese medicine can promote the proliferation, migration and differentiation neural stem cells in the subependymal zone after cerebral infarction. Neural stem cell transplantation in the treatment of cerebral infarction has yielded progress, but there are still many issues that need to be resolved in the future.

关 键 词：干细胞 干细胞学术探讨 干细胞移植 神经干细胞 脑梗死 神经细胞 巢蛋白 5-溴脱氧尿嘧啶 针灸 中医药 细胞因子 中国临床试验注册 

分 类 号：R394.2[医药卫生—医学遗传学]