根除幽门螺杆菌对幽门螺杆菌阳性反流性食管炎患者的影响  

Effect of eradicating helicobacter pylori on the positive helicobacter pylori patients with reflux esophagitis

作　　者：廉华[1] 王文兵[1] 张文礼[1] 周涛[1] 胡莲[1] 

机构地区：[1]四川省宜宾市第一人民医院消化科,四川宜宾644000

出　　处：《实用临床医药杂志》2013年第17期129-131,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321125)

摘　　要：目的探讨根除幽门螺杆菌(HP)对HP阳性反流性食管炎患者的影响。方法将160例HP阳性反流性食管炎患者随机分为研究组和对照组,每组80例。研究组接受根除HP治疗,对照组接受抑酸治疗,比较2组患者的症状疗效、症状评分、内镜下疗效、治疗前后24 h食管pH值监测结果以及复发情况。结果治疗8周及12个月后,2组症状评分均较治疗前显著降低;治疗12个月后,2组症状评分均显著高于治疗8周后,但研究组升高程度显著小于对照组。治疗后,2组pH值<4反流次数、反流持续时间≥5 min反流次数、最长反流持续时间、pH值<4总时间及pH值<4时间百分比均较治疗前明显减少;但治疗后2组间比较,差异无统计学意义。研究组平均复发时间显著晚于对照组,差异有统计学意义。结论根除HP治疗HP阳性反流性食管炎与抑酸治疗疗效相当,在未加重患者临床症状的前提下,可明显延缓复发。Objective To explore the effect of eradicating helicobacter pylori （HP） on the positive HP patients with reflux esophagitis. Methods A total of 160 positive HP patients with re- flux esophagitis were randomly divided into research group and control group, 80 cases in each group. The research group was treated with eradication of HP, while the control group with acrid suppression. The symptomatic effects and scores, endoscopic effects, esophageal pH monitoring re- suits 24 h before and after treatment as well as the recurrence conditions were compared in the two groups. Results Eight weeks and 12 months after the treatment, the symptomatic scores in two groups decreased obviously. 12 months after treatment, those in the two groups were significantly higher than the 8th week, but the increased degree in the research group was evidently smaller than that in the control group. After treatment, the reflux times with pH value 〈 4, times with reflux persistent time ~5 min, the longest reflux persistent time, total time of pH value 〈 4 and its time percentage in the two groups were reduced. But after treatment, there were no significant differ- ences in two groups regarding these aspects. The mean recurrence time in the research group was apparently later than that in the control group, and the statistical significance was presented. Con- clusion The therapeutic effect of eradicating HP is similar to suppression of acrid in the treatment of positive HP reflux esophagitis. Without aggravation of clinical symptoms, it can prolong the re- currence.

关 键 词：幽门螺杆菌 反流性食管炎 抑酸 症状 复发 

分 类 号：R571[医药卫生—消化系统]