结直肠癌根治术后复发转移的危险因素分析  

Analysis of the Risk Factors of Postoperative Recurrence for Elderly Patients with Colorectal Cancer

作　　者：蒋正财[1] 

机构地区：[1]温州医学院第二附属医院普外科,浙江省温州市325000

出　　处：《中华全科医学》2013年第11期1676-1678,共3页Chinese Journal of General Practice

摘　　要：目的分析结直肠癌根治术后复发转移的影响因素及预后。方法回顾性分析接受手术治疗的结直肠癌患者的临床资料。分析老年结直肠癌患者术后5年复发率；影响老年直肠癌术后5年复发率的单因素及多因素分析。结果老年结直肠癌术后5年的复发率为25．23％（82／325）。单因素分析发现，性别、肿瘤部位、是否发生梗阻、肿瘤直径及肿瘤大体类型对老年结直肠癌术后5年复发率并无影响。年龄≥65岁、围手术期接受输血治疗、病理分级低、原发瘤为T3～T4期、有淋巴结转移以及有脉管瘤栓的患者术后5年复发率显著升高（P〈0．05）。接受辅助化疗的患者术后5年复发率显著低于未接受辅助化疗的患者（P=0．022）。Cox回归分析发现原发瘤为T3～T4期、围手术期输血、有淋巴结转移及有脉管瘤栓是导致老年结直肠癌患者术后5年复发率升高的独立风险因素。结论加强复发高危人群的随访工作有望早期发现复发并及时干预。Objective Our retrospective study was aimed to analyzed the risk factors of postoperative recurrence for elderly patients with colorectal cancer. Methods Clinical data of colorectal cancer patients received surgery treatment at our hospital from 2003 to 2008 was retrospectively analyzed. Results A total of 325 patients were analyzed, the rate of postoperative recur-rence was 25.23%（82/325 ）. Cox regression analysis showed that T3-T4 perioperative （ P = 0. 015 ） , blood transfusion （ P = 0. 032 ） , lymph node metastasis（ P = 0. 018 ） and blood vessel invasion （P = 0. 026）were the independent risk factors of recur- rence after surgery treatment in five years for elderly patients with colorectal cancer. Conclusion Recurrence of high-risk groups of follow-up work was expected to early detection of recurrence and timely intervention.

关 键 词：结直肠癌 手术 术后复发 风险因素 预后 

分 类 号：R735.35[医药卫生—肿瘤] R735.36[医药卫生—临床医学]