急性脑梗死与相关载脂蛋白关系的研究  

Research of Correlation Between Acute Cerebral Infarction and Its Related Apolipoproteins

作　　者：李有中[1] 谢康[1] 冯敏[1] 郑重[1] 寿广丽[1] 朱方方[1] 

机构地区：[1]蚌埠医学院第二附属医院神经内科,安徽省蚌埠市233040

出　　处：《中华全科医学》2013年第11期1712-1712,1797,共2页Chinese Journal of General Practice

摘　　要：目的探讨急性脑梗死与载脂蛋白B、载脂蛋白A1及载脂蛋白B/载脂蛋白A1关系。方法选择2012年12月-2013年7月蚌埠医学院第二附属医院住院的急性脑梗死患者60例作为脑梗死组,其中男性40例,女性20例;随机选择同期健康体检者19例作为对照组,其中男性11例,女性8例,所有受检者均禁食12 h以上,清晨空腹抽取静脉血4 ml,采用全自动生化仪测定载脂蛋白B、载脂蛋白A1水平,并进行相关统计学分析。结果脑梗死组患者载脂蛋白B、载脂蛋白B/载脂蛋白A1水平高于对照组(P<0.05),血清载脂蛋白A1水平显著低于对照组(P<0.05)。结论急性脑梗死患者的血清载脂蛋白B、载脂蛋白B/A1可能为脑梗死的危险因素;载脂蛋白A1可能是脑梗死发病风险的保护因素。Objective To evaluate the association of serum ApoB,ApoA1 and ApoB/A1 levels and acute cerebral infarction.Methods Randomly selecting 60 cases of acute cerebral infarction from December 2012 to July 2013 in our hospital inpatient,of which 40 cases were male ,20 cases were female. Randomly selecting 19 cases as control group ,which were from our hospital for the healthy crowd, of which 11 cases were male,8 cases were female. All subjects were targeted within 12 hours after in the hospi- tal fasting 4 ml venous blood. Serum concentrations of ApoB and ApoA1 were measured by automatic biochemical analyzer. Re- sults The serum level of ApoB and ApoB/ApoA1 of acute cerebral infarction were found significantly higher than those of the control group（P 〈 0.05 ）, while serum ApoA1 level was found significantly lower（ P 〈 0.05 ）. Conclusion The serum ApoB, ApoB/ApoA1 levels of patients with acute cerebral infarction may be a risk factor for cerebral infarction;while ApoA1 level may be a protective factor.

关 键 词：脑梗死 载脂蛋白B 载脂蛋白A1 

分 类 号：R743.33[医药卫生—神经病学与精神病学] I341[医药卫生—临床医学]