海岛居民脑梗死危险因素的病例对照研究  

Case control study on risk factors of cerebral infarction in island residents

作　　者：邹飒枫[1] 段春梅[1] 时景璞[2] 王怡[1] 潘心[1] 吴晓梅[2] 张文良[2] 

机构地区：[1]大连市中心医院神经病学教研室,辽宁大连116033 [2]中国医科大学附属第一医院临床流行病教研室,辽宁沈阳110001

出　　处：《中风与神经疾病杂志》2013年第10期928-930,共3页Journal of Apoplexy and Nervous Diseases

基　　金：大连市科学技术基金计划项目(2009E12SF149)

摘　　要：目的探索大连市海岛居民发生脑梗死可能的危险因素。方法采用整群随机抽样法，选择大连市长海县的海岛居民为研究对象。对符合诊断标准的病例按照1：2配对病例对照研究设计进行分析。采用Logistic回归模型对脑梗死的相关危险因素进行单因素和多因素回归分析。结果单因素条件Logistic回归分析结果显示：文化程度、冠心病、高血压、舒张压、甘油三脂、胆固醇、低密度脂蛋白、血清脂蛋白与该海岛地区居民脑梗死的发生有关。多因素条件Logistic回归分析结果显示：舒张压（OR=1．045，OR95％CI=1．013—1．076）、教育程度（OR=1．546，OR95％C1=1．032～2．318）是该海岛地区脑梗死主要的危险因素，而高密度脂蛋白（OR=0．094，OR95％CI=0．023～0．377）是该海岛居民脑梗死发生的保护因素。结论舒张压、教育程度是该海岛地区居民脑梗死的危险因素，而HDLC是保护因素。因此，针对该地区脑梗死的预防与治疗应结合该地区的发病特点有针对性的干预。Objective To investigate the possible risk factors for cerebral infarction （cerebral ischemic stroke） in the island residents. Methods Cluster random sampling method was used for data collection. Dalian Changhai County resi- dents were the investigation objects. Those cases that met the diagnostic criteria were analyzed in accordance with the 1： 2 matched case-control study method. Comparisons were made among the patients matched in the ethnicity, gender, age （with- in ~ 3 years） in the living area（ neighboring the ocean）. Data meeting the requirements were compiled in Excel 2007 and were analyzed by SPSS16.0 and ASA9.1 software. Univariate and multivariate logistic regression analyses were performed to identify the risk factors for cerebral infarction, and to calculate OR and 95% CI for various related factors associated with cerebral infarction. Results Univariate logistic regression analysis showed the education level, coronary heart disease, hy- pertension, diastolic pressure, triglyeeride, cholesterol, low-density lipoprotein, and serum lipoprotein each had close associa- tions with the incidence of cerebral infarction among the ocean-side residents. Multivariate logistic regression analysis showed the diastolic pressure（ OR = 1. 045, OR 95% CI = 1. 013 ~ 1. 076） and educational level were the main risk factors for cerebral infarction among the ocean-side residents. High-density lipoprotein （ HDLC ; OR = 0. 094, OR 95% C1 = 0.023 0. 377） was a protective factor for the occurrence of cerebral infarction. Conclusion The diastolic blood pressure and the educational level were the main risk factors for cerebral infarction in residents of this area, while HDLC was a protective fac- tor in this island population.

关 键 词：脑梗死 海岛地区居民 危险因素 条件LOGISTIC回归分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]