miRNAs在疼痛中的研究进展  

Research progress of miRNAs in pain

作　　者：李桂霞[1] 李春莉[1] 吴春福[1] 

机构地区：[1]沈阳药科大学药理学教研室,辽宁沈阳110016

出　　处：《中国药理学通报》2013年第11期1485-1488,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81073081)

摘　　要：miRNAs是一种内源性的非编码小分子RNA,长约18～25个核苷酸。能够通过碱基互补配对原则特异性地与一个或多个靶基因的mRNA结合,导致mRNA降解或者抑制其翻译过程,从而在转录后水平沉默靶基因,起到调控作用。Bai等发现外周神经系统存在很多miRNAs,外周炎性刺激可引起其中一些miRNAs的表达变化,推测在疼痛的发生机制中miRNAs可能发挥了重要的作用。因此,对miRNAs在疼痛中的调控作用进行研究,对镇痛药物研发及应用具有重要的意义。miRNAs, contrast to siRNAs, are a class of endogenously non-coding small RNAs of 18-25 nucleotides. By specifically binding to their target mRNA sequence, they silence genes either through initiating the cleavage or inhibiting gene translation to play regulatory roles. Bai has assumed that a lot of miRNAs are located in peripheral nervous system, and peripheral inflamatory stimulation could induce great changes of some miRNAs.These results indicate that small molecular RNA plays an important role in the pathophysiology of pain. Therefore, to study the regulatoU role of miRNAs in pain has important implications for the development and application of analgesic drugs.

关 键 词：微小RNA 异常表达 调控 炎性疼痛 神经病理性疼痛 治疗靶点 

分 类 号：R-05[医药卫生] R441.1