吗啡不同给药方式对缓解中重度癌痛的效果观察  

OBSERVATION OF THE EFFECT OF MORPHINE IN DIFFERENT ADMINISTRATIVE METHODS ON RELIEF OF MODERATE TO SEVERE CANCER PAIN

作　　者：刘莹[1] 黄珊[1] 刘月彬[1] 

机构地区：[1]南京军区福州总医院药学科,福州350025

出　　处：《中国药物依赖性杂志》2013年第5期347-349,共3页Chinese Journal of Drug Dependence

摘　　要：目的:比较吗啡不同给药方式治疗中重度癌痛患者的镇痛效果及不良反应。方法:选择某院2011年6月-2012年6月收治的60例中重度癌痛住院患者,随机分成3组,每组20例:A组口服给药,B组静脉泵入给药,C组皮下注射给药。评价吗啡对3组患者的镇痛效果和不良反应。结果:吗啡3种不同给药方式镇痛的起效时间分别为A组(85.5±s 48.5)min,B组(28.0±s 8.6)min,C组(48.5±s 22.6)min,3组起效时间差异有统计学意义(F值F=34.844,P<0.05);3组不同给药方式镇痛的最佳缓解时间分别为A组(163.0±s 69.9)min,B组(61.0±s 18.6)min,C组(78.0±s 34.0)min,3组癌痛最佳缓解时间差异有统计学意义(F=9.196,P<0.05);3组不同给药方式的主要不良反应为:便秘、头晕、恶心/呕吐、嗜睡、尿潴留等,3种给药方式不良反应发生率无显著性差异(P>0.05)。结论:吗啡静脉泵入给药起效快,可以迅速缓解癌痛且提高了患者的依从性,值得在临床上推广。Objecti：To compare the analgesic effect of different administration ways of morphine on the treatment of patients with moderate to severe cancer pain, and its adverse effects. Metrandomized clinical trial was performed on 60 hospitalized patients with moderate to severe cancer pain during June 2011 to June 2012, which were divided into three groups （20 cases per group） ：（A） oral administration group, （B） intravenous pump infusion group, （ C ） sucutaneous injection group. R.esu/ts： The onset time of morphine analgesic effect in three different ways was： （A） group （ 85.5 ± s 48. 5 ） min, （B） group （28. 0 ± s 8. 6） min and （C） group （48. 5 ± s 22. 6） min respectively. The onset time of analgesic effect was significantly different（F =34. 8d4,P 〈0. 05）. The best time to ease the analgesic of 3 groups was（A） group（ 163.0 ±s 69. 9）min, （B）group（61.0 ±s 18. 6）min and（C） group（78. 0 ±s 34. 0）min respectively.The difference of best time to ease pain in three groups was significantly different（ F =9. 196,P 〈0. 05）. The main adverse effects in three groups were constipation, dizziness,nausea,vomiting, sleepines and urinary retention,etc. The rate of adverse effects in three groups was not significantly different （P 〉 0. 05 ）. Conclusion：Intravenous morphine pump infusion has a rapid onset action,can relieve pain and improve the compliance of patients,and is worthy of clinical popularization.

关 键 词：吗啡 给药方式 癌症镇痛 不良反应 

分 类 号：R730.53[医药卫生—肿瘤]