IPS e.max Press铸瓷全冠修复前后龈沟液中IFN-γ、TNF-α、MMP-2的测定及其临床意义  

Mensurement of IFN-γ,TNF-α,and MMP-2 in gingival crevicular fluid before and after IPS e.max Press ceramic crown and their clinical significance

作　　者：唐雄飞[1] 孙振学[1] 王晓颖[1] 董蕾[2] 孟晶[1] 郑天亮[1] 

机构地区：[1]武警总医院机关门诊部口腔科,北京100089 [2]安徽医学高等专科学校,合肥230601

出　　处：《武警医学》2013年第10期895-897,共3页Medical Journal of the Chinese People's Armed Police Force

基　　金：武警部队后勤科研项目(编号WJHQ2012-24)

摘　　要：目的探讨IPS e.max Press铸瓷全冠修复对牙周组织的影响。方法选择IPS e.max Press铸瓷全冠修复患者79例107颗患牙,在修复前和修复后6个月,测定龈沟液(gingival crevicular fluid,GCF)量,并采用酶联免疫吸附试验(ELISA)分别对龈沟液中干扰素-γ(IFN-γ)、肿瘤坏死因子(TNF-α)、基质金属蛋白酶-2(MMP-2)水平进行分析。结果修复后GCF量、IFN-γ、TNF-α、MMP-2水平与修复前比较差异无统计学意义(P>0.05)。结论 IPS e.max Press铸瓷全冠对牙周组织无明显影响,是一种生物相容性良好的修复方式。Objective To observe the effects of IPS e.max Press ceramic crown on the periodontal tissue of the prosthetic teeth. Methods 79 clinical patients（107 anterior teeth）were selected to receive prosthesis with IPS e.max press ceramic crown ,and before and 6 months after prothesis,the weight of gingival crevicular fluid （GCF） was measured and the level of interferon-γ（IFN-γ）,tumor necrosis factor-α（TNF-α） and matrix metalloproteinase-2 （MMP-2） in GCF was checked by enzyme-linked immunosorbent assay,and the result was analyzed. Results The weight of GCF,the level of IFN-γ,TNF-α,MMP-2 in GCF after prosthesis had no statistically significant difference with those before prosthesis （P〉0.05）. Conclusions IPS e.max press ceramic crown has no significant negative influence on gingival health of the restored teeth. And it is a kind of restoration with favorable biocompatibility.

关 键 词：IPS e max Press铸瓷全冠 龈沟液 干扰素-Γ 肿瘤坏死因子 基质金属蛋白酶-2 

分 类 号：R781.4[医药卫生—口腔医学]