Cu（I）-Catalyzed Synthesis of 2-Substituted Benzimidazoles from 2-lodoanilines and Amides  

作　　者：Hua Yuan Yongxin Chen Jinli Song Chunxia Chen Baohua Chen 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China [2]Key Laboratory of Nonferrous Metal Chemistry andResources Utilization of Gansu Province, Lanzhou, Gansu 730000, China

出　　处：《Chinese Journal of Chemistry》2013年第10期1247-1249,共3页中国化学（英文版）

基　　金：Acknowledgement We are grateful for support of this project by the National Natural Science Foundation of China （No. J1103307） and the project of Science Foundation of Gansu Province （No. 1208RJZA266）.

摘　　要：A novel and efficient approach to the synthesis of 2-substituted benzimidazoles has been developed via CuI/DMEDA-catalyzed coupling reaction and post-cyclization with glacial acetic acid from readily available 2-iodoanilines and amides. This method is suitable for the construction of a variety of benzimidazoles in moderate to good yields under short reaction times.A novel and efficient approach to the synthesis of 2-substituted benzimidazoles has been developed via CuI/DMEDA-catalyzed coupling reaction and post-cyclization with glacial acetic acid from readily available 2-iodoanilines and amides. This method is suitable for the construction of a variety of benzimidazoles in moderate to good yields under short reaction times.

关 键 词：2-substituted benzimidazoles CuI/DMEDA 2-iodoanilines AMIDES synthesis 

分 类 号：O625.511[理学—有机化学] TE986[理学—化学]