T_1非小细胞肺癌淋巴结转移规律及临床意义  

Clinical analysis of lymph nodes etastasis in T_1 non-small cell lung cancer

作　　者：甄福喜[1] 张憬[1] 王俊[1] 赵飞[1] 陈海兵[1] 陈亮[1] 

机构地区：[1]南京医科大学第一附属医院胸心外科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2013年第10期1419-1421,共3页Journal of Nanjing Medical University(Natural Sciences)

基　　金：中华国际医学交流基金(CIMF-F-H001-244)

摘　　要：目的：探讨T1非小细胞肺癌（NSCLC）淋巴结转移的规律和特点。方法：回顾性分析2011年1月．2012年11月276例行手术治疗T1 NSCLC患者的临床资料，分析淋巴结分布情况及临床病理特征并进行统计学分析。结果：①276例中66例经病理证实伴淋巴结转移，转移率为23．9％（66／276），高、中低分化NSCLC的胸腔内淋巴结转移率分别为6．1％和33．7％，差异显著（P〈0．05）；②右肺中叶较右肺上叶、左肺下叶更易发生胸腔内淋巴结转移（x2=5．545，P〈0．05和x2=5．402，P〈0．05）。66例淋巴结转移患者中，各肺叶肿瘤均存在淋巴结跳跃性转移，但无明显统计学差异。结论：在T1 NSCLC中，右肺中叶较易发生胸腔内淋巴结转移，肺癌淋巴结转移频度与肿瘤分化程度相关，且存在跳跃式转移的特点，故针对T1 NSCLC行肺切除术时施行系统性纵隔淋巴结清扫是非常必要的。Objective：To investigate the characteristics of lymph nodes metastasis in T1 non-small cell lung cancer （NSCLC）. Methods：The clinical data of 276 cases underwent resection of NSCLC from January 2011 to November 2012 were analyzed retrospectively. Characteristics of tumors,lymph nodes involvement were analyzed in those cases. Results： （1） In all 276 cases, 66 cases were confirmed pathology with lymph node metastasis,metastasis rate was 23.9% （66/276）. The metastatic rates in group of well differentiated and poorly differentiated were 6.1% and 33.7% respectively,the difference being significant （P 〈 0.05）. （2） The frequency of metastasis was higher in patients with a primary tumor in the right middle lobe compared to the right upper and left lower lobe （X2 = 5.545 ,P 〈 0.05 and X2 = 5.402,P 〈 0.05）. Conclusion：In T1 NSCLC,lymph nodes metastatic rate is closely related with the degree of tumor differentiation. The frequency of metastasis was higher in patients with a primary tumor in the right middle lobe. It is necessary to perform systematic node dissection during pulmonary resection for those patients.

关 键 词：T1 非小细胞肺癌 淋巴转移 

分 类 号：R734.2[医药卫生—肿瘤]