ERCC1及C-erbB2在子宫内膜癌组织中的表达及其对中西医结合疗效的影响  

Expressions of ERCC1 and C-erbB2 in endometrial carcinoma tissue and their impact on the therapeutic effect of integrated Chinese and Western medicine

作　　者：冯文[1,2] 房瑜[3,4] 杨成喜[1,5] 

机构地区：[1]江苏省连云港市第一人民医院 [2]徐州医学院附属连云港医院妇科,江苏连云港222002 [3]江苏省连云港市第一人民医院徐 [4]州医学院附属连云港医院妇科,江苏连云港222002 [5]徐州医学院附属连云港医院肿瘤内科,江苏连云港222002

出　　处：《山东大学学报（医学版）》2013年第10期81-84,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨核苷酸切除修复交叉互补基因(ERCC1)和人表皮生长因子(C-erbB2)在子宫内膜癌组织中的表达及其对化疗联合舒肝益肾方疗效的影响。方法将51例子宫内膜癌患者作为子宫内膜癌组,20例子宫内膜正常者为对照组。子宫内膜癌组给予化疗联合中药疏肝益肾方治疗。检测2组子宫内膜组织中ERCC1及C-erbB2表达,分析子宫内膜癌患者组织中C-erbB2、ERCC1表达对中西医结合治疗子宫内膜癌疗效的影响。结果 C-erbB2、ERCC1在子宫内膜癌组织中阳性表达随组织学分级增加而增强,G3级C-erbB2阳性率明显高于G1级和G2级(P<0.05);G3级的ERCC1阳性率明显高于G1级(P<0.05)。C-erbB2、ERCC1在子宫内膜癌组中阳性表达率明显高于对照组(P<0.05或P<0.01)。子宫内膜癌组C-erbB2、ERCC1阳性表达者的中西医结合疗效明显低于C-erbB2、ERCC1阴性表达者(P<0.05)。结论 ERCC1和C-erbB2表达状态有利于判断子宫内膜癌病理分级,并可用于疗效评估。Objective To investigate the expressions of nucleotide excision repair cross-complementing gene （ERCC1） and human epidermal growth factor （C-erbB2） in endometrial carcinoma tissue and their impact on the therapeutic effect of chemotherapy combined with liver-soothing kidney-tonifying formula. Methods Fifty-one patients with endo- metrial cancer and 20 subjects with normal endometrium were respectively as endometrial carcinoma group and control group. The former was treated with chemotherapy combined with liver-soothing kidney-tonifying formula. The expres- sions of ERCC1 and C-erbB2 in endometrial tissue of two groups were detected, and the impact of C-erbB2 and ERCC1 expressions on the therapeutic effect of integrated Chinese and Western medicine was analyzed. Results The positive expressions of C-erbB2 and ERCC1 in endometrial cancer tissue were increased with histological grading increasing. C-erbB2 positive rate at grade G3 was significantly higher than at grades G~ and G2 （ P 〈 0.05 ）, and ERCC1 positive rate at grade G3 significantly higher than at grade G~ （ P 〈 0.05 ）. Positive expression rates of C-erbB2 and ERCC1 in endometrial cancer group were significantly higher than in control group （ P 〈 0.05 or P 〈 0.01 ）. The therapeutic effect of integrated Chinese and Western medicine on patients with positive expressions of C-erbB2 and ERCC1 was signifi- cantly lower than that with negative ones （ P 〈 0.05 ）. Conclusion ERCC1 and C-erbB2 expressions are conducive to determining the pathological grading of endometrial carcinoma, and can be used to assess the therapeutic effect.

关 键 词：子宫内膜癌 核苷酸切除修复交叉互补基因 癌基因人表皮生长因子 舒肝益肾方 

分 类 号：R737.33[医药卫生—肿瘤]