17例涎腺淋巴上皮癌临床病理分析  

Lymphoepithelial carcinoma in salivary glands:clinical and pathological analysis of 17cases

作　　者：殷学民[1,2] 徐国翔[3] 张磊涛[1,2] 陈之锋[1,2] 刘啸[1,2] 张君伟[1,2] 

机构地区：[1]南方医科大学南方医院口腔颌面外科 [2]南方医科大学口腔医学院,广州510515 [3]广州市红十字会医院口腔颌面外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2013年第21期1171-1174,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：广东省自然科学基金(No:S2011010003872);广州市科技计划项目(No:7421165457455)

摘　　要：目的:涎腺淋巴上皮癌是一种罕见的恶性肿瘤,本文主要探讨涎腺淋巴上皮癌的发病情况、病理特点及其诊治措施。方法:回顾性分析2006-2012年间于南方医科大学南方医院就诊的17例涎腺淋巴上皮癌患者,分析其临床特点与治疗方法对预后的影响。结果:17例中,男10例,女7例;Ⅱ、Ⅲ、Ⅳ期患者分别为7(41.2%)、4(23.5%)、6(35.3%)例。术后平均随访时间为2.56年,随访12例患者情况稳定;5例患者分别在术后3年内出现局部复发和(或)远处转移,其中4例已死亡。结论:涎腺淋巴上皮癌是头颈部恶性程度较高的肿瘤之一,好发于腮腺及下颌下腺。治疗应行原发灶扩大切除及根治性颈淋巴清扫术,并结合放化疗以提高疗效。Objective：Lymphoepithelial carcinoma（LEC） of salivary glands is a rare malignant neoplasm. The purpose of this research was to investigate the clinicalpathologic features and treatment methods of this rare disease. Method：The clinical data and treatment outcomes of 17 patients from 2006 to 2012 were reviewed retrospectively. Result： Ten males and seven females with a ratio of 1.43：1 were involved. The Ⅱ , Ⅲ , Ⅳ stage cases were 7（41.2%）, 4（23.5%）, 6（35.3%）, respectively. The average follow-up duration was 2.56 years, and 12 pa- tients had no evidence of recurrence. Five patients had local recurrence and （or） distant metastases within three years after surgery, including 4 deaths. Conclusion：LEC in salivary gland is a high grade malignant tumor in oral and maxillofacial region, occurring predominately in parotid gland and submandibular gland. To prevent distant metastasis, radical surgery combined with chemoradiotherapy should be adopted.

关 键 词：涎腺肿瘤 淋巴上皮癌 未分化癌 

分 类 号：R739.6[医药卫生—肿瘤]