氟西汀治疗对神经性厌食症患者事件相关电位N400的影响  

Effect of luoxetine on N400 of semantic matching of sentence-ending words in anorexia nervosa

作　　者：朱红梅[1] 汪艳[1] 

机构地区：[1]南京医科大学附属无锡精神卫生中心精神科,江苏无锡214151

出　　处：《中国现代医学杂志》2013年第25期65-68,共4页China Journal of Modern Medicine

摘　　要：目的探讨氟西汀对神经性厌食症患者汉语句子的事件相关电位N400的影响。方法随机将年龄在18～60岁之间符合CCMD-3神经性厌食症标准患者32例作为实验组,选择性别、年龄及文化程度匹配的32例健康者作为对照组,两组分别予汉语句子N400检测。实验组予氟西汀治疗8周,分别比较实验组对照组以及实验组治疗前后N400潜伏期及波幅的差异。结果实验组FZ点潜伏期均比对照组延长,波幅均比对照组降低(P<0.05及0.01);实验组治疗后比治疗前N400波幅升高,潜伏期缩短(P<0.05或P<0.01)。结论神经性厌食症患者存在认知功能异常,氟西汀具有改善神经性厌食症患者认知功能的作用。[ Objective ] To study the Effect of Fluoxetine treatment on N400 of semantic matching of sentence- ending words in anorexia nervosa. [ Methods ] 30 patients （among 18-60 years old） met with CCMD-3 for anorexia nervosa criteria were selected as research group. 30 healthy individuals marched sexual, age and educational level was selected as normal control group. Fluoxetine was employed in research group for 8 weeks. N400 latencies and amplitudes of all groups were compared respectively. [ Results ] N400 latencies prolonged and the amplitudes shortened in research group compared with normal control group（P 〈0.05 or P 〈0.01）. After treatment, N400 latencies reduced and the amplitudes hoisted in research group 1, 2 （P 〈0.05 or P 〈0.01）; N400 lateneies reduced and the amplitudes shortened in research group 2 compared with research group 1 （P 〈0.05 or P 〈0.01）. [Conclusions] Anorexia nervosa presentshavecognitive dysfunctions, and fluoxetine could improve the cognitive function in anorexia nervosa.

关 键 词：神经性厌食症 事件相关电位N400 氟西汀 认知功能 

分 类 号：R745[医药卫生—神经病学与精神病学]