高原藏族人群胃癌发病危险因素病例对照研究  

Epidemiological study on risk factors of gastric cancer among tibetan popolation in plateau area

作　　者：李康[1] 旦增[1] 刘晓波[1] 刘明花[1] 泽永革[2] 次仁措姆[2] 边巴扎西[2] 

机构地区：[1]西藏自治区人民医院消化科,西藏拉萨850000 [2]西藏自治区人民医院肿瘤科

出　　处：《中国公共卫生》2013年第11期1613-1615,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金(81060206)

摘　　要：目的 了解西藏高原地区藏族人群胃癌患病的相关危险因素,为制订有效胃癌防治策略提供依据。方法 采用1：1配对病例对照研究方法,在西藏自治区人民医院对116例新发的胃癌患者及116名同期参加健康体检人群进行问卷调查,分析胃癌发病的影响因素。结果 单因素logistic回归分析结果显示,常生闷气（OR=2.812）、吸烟（OR=1.908）、饮食不规律（OR=2.484）、慢性胃炎（OR=2.164）、胃溃疡（OR=2.105）、肿瘤家族史（OR=3.367）、高盐饮食（OR=2.792）、粗糙食物（OR=2.337）、干硬食物（OR=3.164） 为高原地区胃癌发病的主要危险因素;多因素logistic回归分析结果显示,饮食不规律（OR=2.912,95%CI=1.099-7.718）、长期食用干硬食物（OR=2.580,95%CI=1.155-5.765）、喜食高盐饮食（OR=2.653,95%CI=1.287-5.469）、慢性胃炎病史（OR=2.254,95%CI=1.141-4.419）及肿瘤家族史（OR=3.356,95%CI=1.167-9.652）是高原藏族人群胃癌发生的主要危险因素。结论 高原地区胃癌的发病可能与不良的饮食习惯、长期患有胃病史以及肿瘤家族史有关,应因地制宜制定科学的预防措施。Objective To examine the risk factors of gastric carcinoma among Tibetan people living in Tibet plateau,and to provide reference for making effective strategy to prevent gastric carcinoma.Methods A 1：1 matched case-control study was conducted among 116 new diagnosed gastric cancer patients and 116 healthy physical examinees over the same period in Tibet Region People＇s Hospital with a questionnaire survey.Results Univariate logistic regression analyses showed that the main risk factors for gastric cancer in the high-altitude region were sulking（odds ration[OR]=2.812）,smoking（OR=1.908）,eating disorders（OR=2.484）,chronic gastritis（OR=2.164）,gastric ulcer（OR=2.105）,family history of tumor（OR=3.367）,high-salt diet（2.792）,rough food（OR=2.337）,and dry and hard food（OR=3.164）.Multiyariate logistic regression analyses showed that the main risk factors for gastric carcinoma in the high-altitude region were eating disorders（OR=2.912,95% confidence interval[95%CI]：1.099-7.718）,taking dry and hard food for a long time（OR=2.580,95%CI：1.155-5.765）,salty food（OR=2.653,95%CI：1.287-5.469）,history of chronic gastritis（OR=2.254,95%CI：1.410-4.419） and family history of cancer（OR=3.356,95%CI：1.167-9.652）.Conclusion The incidence of gastric carcinoma in plateau area may correlate with unhealthy dietary habit,long-time history of chronic gastric diseases,and familial history of carcinoma.Specific preventive measures should be taken to control the disease according to the unique local condition.

关 键 词：胃癌 高原地区 危险因素 病例对照研究 

分 类 号：R573[医药卫生—消化系统]