补肾活血中药辅助治疗对帕金森病患者抑郁症状的影响  

Effect of Bushen Huoxue Herbs on Depression of Patients with Parkinson's Disease

作　　者：李敏[1] 刘毅[1] 冯宇[1] 王海明[1] 任芳[1] 

机构地区：[1]解放军总医院中医医院,北京100853

出　　处：《中药材》2013年第8期1375-1378,共4页Journal of Chinese Medicinal Materials

基　　金："十一五"国家科技支撑计划重大项目(2006BAI04A11)

摘　　要：目的:研究补肾活血中药对帕金森病(Parkinson's disease,PD)患者抑郁症状的影响。方法:将96例PD伴发抑郁症状患者随机分成治疗组46例和对照组50例。两组均以西药为基础治疗,其中治疗组加服补肾活血中药。两组患者均以9个月为疗程。采用汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)及脑电超慢涨落图技术(Encephalofluctuograph Technology,ET)观察患者在入组时、治疗3个月、6个月、9个月后的量表评分及脑内部分神经递质水平变化。结果:治疗组患者脑内5-羟色胺(5-hydroxytryptamine,5-HT)、去甲肾上腺素(noradrenaline,NE)、多巴胺(Dopamine,DA)测定值较治疗前显著升高(P<0.05或P<0.01);治疗后治疗组患者脑内5-HT、DA测定值显著高于对照组(P<0.05),HAMD评分显著低于对照组(P<0.05)。研究过程中未发现明确不良反应。结论:补肾活血中药能提高PD患者脑内5-HT、NE、DA水平,降低HAMD量表评分,有效改善PD患者的抑郁症状。Objective：To study the effect of Bushen Huoxue Herbs on depression of patients with Parkinson＇s disease. Methods： Ninety-six patients were randomized into two groups with 46 patients in the treatment group and 50 patients in the control group. Both groups took western medicine as basic treatment. The treatment group was treated with Bushen Huoxue Herbs additionally. The observa- tion was carried out for 9 months. Used Eneephalofluctuograph Technology（ET） and Hamilton Depression Scale （HAMD）to measure the changes of cerebral neurotransmitters and scale scores in both groups at baseline time,3,6 and 9 months later to evaluate the effects of Bushen Huoxue Herbs. Results ： In the treatment group,5-hydroxytryptamine （5-HT） , noradrenaline （ NE ） and dopamine （ DA ） levels were increased significantly when compared with pretreatment（ P 〈 0. 05 ）, especially of 5-HT and DA levels（ P 〈0. 01 ） ;Compared with the control group,5-HT and DA levels were increased significantly （ P 〈 0. 05 ）. After treatment, the scores of the HAMD scale was signifi- cantly decreased（ P 〈 0. 05 ）. No adverse effects were found in this trial. Conclusion ： Bushen Huoxue Herbs can improve depression of PD patients by increasing the levels of 5-HT,NE and DA in the brain and decreasing the scores of the HAMD scale with reliable effects.

关 键 词：帕金森病 中药 抑郁症状 

分 类 号：R742.5[医药卫生—神经病学与精神病学]