良性脑膜瘤患者术后短期预后的相关因素分析  

Analysis of relevant factors of early post-operative prognosis of benign meningiomas

作　　者：王加充[1] 赵建农[1] 王鹏程[1] 彭其斌[1] 王义彪[1] 

机构地区：[1]海南省人民医院神经外科,海口570311

出　　处：《中国实用神经疾病杂志》2013年第19期8-9,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨良性脑膜瘤患者术后短期预后的相关因素。方法回顾性分析我院2005-07—2012-05收治的217良性脑膜瘤患者的临床资料,根据所有患者手术前后Karnofsky生活质量评分的差异将其分为预后良好组(178例)与预后不良组(39例)。比较2组患者的临床资料,找出良性脑膜瘤患者术后短期预后不良的相关因素。结果多因素Logistic回归分析结果显示,术前合并脑梗死(β=1.304,OR=3.684)、大型脑膜瘤(β=1.452,OR=4.272)、术中发生失血性休克(β=1.539,OR=4.660)、肿瘤切除级别低(β=1.431,OR=4.183)是良性脑膜瘤患者术后短期预后不良的独立危险因素。结论术前合并脑梗死、大型脑膜瘤、术中发生失血性休克、肿瘤切除级别低是良性脑膜瘤患者术后短期预后不良的独立危险因素,对于合并上述因素的患者,应做好预防措施以改善患者预后。Objective To study the relevant factors of early post-operative prognosis of benign meningiomas. Methods The clinical data of 217 patients with benign meningiomas who came to our hospital from June 2005 to May 2012 were retro- spectively analyzed. All the patients were divided into the good prognosis group （178 cases） and bad prognosis group （39 ca- ses） according to the Karnofsky score before and after the surgery. The clinical data of two groups were compared to find out the relevant factors of early post-operative prognosis of benign meningiomas. Results When stepwise multiple logistic regres- sion analysis was employed, preoperative cerebral infarction （β= 1. 304, OR ： 3. 684）, large meningiomas （β= 1. 452, OR ： 4. 272）, intra-operatively hemorrhagic shock （β= 1. 539, OR：4. 660）, low extent of tumor resection （β=1. 431, OR：4. 183） were dependent risk factors of early post-operative prognosis of benign meningiomas. Conclusion Preoperative cerebral infarction, large meningiomas, intra-operatively hemorrhagic shock, low extent of tumor resection and low extent of tumor resection may be dependent risk factors for early post-operative prognosis of benign meningiomas. For the patients with above charac- ters, preventive measures should be taken to improve the prognosis.

关 键 词：良性脑膜瘤 短期预后 相关因素 

分 类 号：R739.45[医药卫生—肿瘤]