尤瑞克林在高龄急性脑梗死治疗中的对照研究  

Comparative study of urinary kallidinogenase in the treatment of acute cerebral infarction in the elderly

作　　者：陈克强[1] 孙巧松[1] 郑红丽[1] 

机构地区：[1]中山大学附属江门医院神经内科,江门529000

出　　处：《中国实用神经疾病杂志》2013年第19期24-26,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的评价尤瑞克林治疗高龄急性脑梗死的临床疗效和安全性。方法 46例高龄急性脑梗死患者随机分为治疗组(n=24)和对照组(n=22),在常规治疗基础上治疗组给予尤瑞克林,对照组给予生理盐水100mL,2组疗程均为14d。在入组时、14d、30d分别对2组患者进行美国国立卫生院卒中量表(NIHSS)及改良Rankin量表(mRS)的评分。结果治疗组14d和30d的NIHSS、mRS评分均优于对照组(P<0.05);2组颅内出血各1例。结论尤瑞克林对高龄急性脑梗死具有肯定的治疗作用,且不增加脑出血风险。Objective To evaluate the clinical effect and safety of urinary kallidinogenase in the treatment of the elderly patients with acute cerebral infarction. Methods Forty-six cases of elderly patients with acute cerebral infarction were randomly divided into the treatment group and control group, on the basis of conventional therapy, treatment group was treated with uri nary kallidinogenase, control group was given normal saline 100 mL, two groups were treated for 14 days. The patients in the two groups were assessed by United States National Institutes of Health Stroke Scale （NIHSS） and modified Rankin scale （mRS） score at the baseline, 14 d and 30 d, respectively. Results The NIHSS and mRS scores in the treatment group of 14 d and 30 d were better than those o~ control group（P〈0. 05） ; intracranial hemorrhage was only 1 case in the treatment group and control group, respectively. Conclusion Urinary kallidinogenase has a positive role in the treatment of senile acute cerebral infarction, and dofft increase the risk of cerebral hemorrhage.

关 键 词：急性脑梗死 尤瑞克林 治疗 

分 类 号：R743.33[医药卫生—神经病学与精神病学]