脑胶质瘤中p16蛋白与PCNA表达及其临床意义  

Significance of p16 and PCNA Expression in Brain Glioma

作　　者：翟广[1] 袁先厚[2] 宋来君[1] 

机构地区：[1]河南医科大学附属第一医院神经外科,450052 [2]湖北医科大学附属第二医院神经外科,430071

出　　处：《实用癌症杂志》2000年第6期569-570,598,共3页The Practical Journal of Cancer

摘　　要：目的　探讨p16蛋白缺失与脑胶质瘤的恶性进展、增殖能力及预后的关系。方法　应用免疫组织化学方法 ,检测了96例不同级别脑胶质瘤存档标本 p16蛋白及增殖细胞核抗原的表达情况。 结果　p16蛋白缺失频率随脑胶质瘤级别的增高而增高 (P <0 .0 1) ;4对复发时级别增高的肿瘤组织均发生了 p16蛋白缺失 ,而另 3对复发时仍保持原来级别者无一发生p16蛋白缺失。同一级别的脑胶质瘤 ,p16蛋白缺失者的PCNA指数明显高于无 p16蛋白缺失者 (P <0 .0 5 )。 结论　p16蛋白缺失与脑胶质瘤的恶性进展及增殖能力有关 ,p16蛋白免疫组织化学检测可作为反映脑胶质瘤预后的 1个指标。Objective To investigate the correlation of p16 expression with malignant progression and proliferating ability of brain glioma.Methods Expression of p16 and PCNA in 96 brain gliomas were detected by immunohistochemistry.Results Deletion rate of p16 protein was increased with the malignance of brain glioma(P<0.01).4 recurrent gliomas with progression of pathological grade had deletion of p16 protein,while deletion of p16 protein wasn′t found in any of the other 3 recurrent gliomas which hadn′t progressed in pathological grade.PCNA index of glioma with deletion of p16 protein was higher than that of one without deletion of p16 protein in the same pathological grade(P<0.05).Conclusion Expression of p16 protein is correlated with malignant progression and proliferating ability of brain glioma.Immunohistochemical detection of p16 protein may act as a prognosis index for brain glioma.

关 键 词：脑胶质瘤 P16蛋白 增殖细胞核抗原 

分 类 号：R739.41[医药卫生—肿瘤]