食管癌组织VEGF的表达与肿瘤血管生成的关系  

Relationship Between Expression of VEGF and Tumor Angiogenesis in Esophageal Carcinomas

作　　者：李宝江[1] 贾玉生[1] 臧长运[1] 马宏岩[1] 曹洪明[1] 叶欣[1] 

机构地区：[1]山东省泰安市中心医院,271000

出　　处：《实用癌症杂志》2000年第6期583-584,共2页The Practical Journal of Cancer

摘　　要：目的　探讨血管内皮生长因子 (VEGF)在食管癌中的表达及其与食管癌血管生成的关系。方法　应用免疫组织化学方法检测 48例食管癌组织中VEGF的表达 ,并对血管进行Ⅷ因子相关抗原的免疫组织化学染色计数。结果　 5 2 .1%的食管癌组织呈VEGF阳性表达 ,VEGF表达和微血管密度 (MVD )值均与肿瘤的临床分期密切相关。VEGF表达阳性食管癌组织的血管密度显著高于VEGF表达阴性者 (P <0 .0 5 ) ,而且随着VEGF表达强度的增强 ,癌组织内血管密度明显增高。结论　VEGF与食管癌组织的生长、浸润和转移有关 ,是食管癌主要的新生血管诱导因子之一 ,可促进食管癌的血管生成。食管癌组织VEGF的检测将可能成为食管癌预后的 1个有用指标 。Objective To evaluate the expression of vascular endothelial growth factor(VEGF) and its relation to angiogenesis in esophageal carcinomas.Methods The expression of VEGF was examined by immunohistochemical staining in 48 cases of esophageal cancer.Microvessel density(MVD) in the cases was determined by Factor Ⅷ immunohistochemical staining.Results VEGF expression was observable in 25 of 48 patients(52.1%).VEGF and MVD were closely related to tumor′s clinical stage.The average MVD was higher in the cases with positive expression of VEGF than that in those without expression of VEGF(P<0.05).Conclusion VEGF is positively correlated with the occurrence、progression and lymphatic invasion of esophageal carcinomas,and is one of the main induction factors for angiogenesis in esophageal carcinoma.It is able to induce tumor angiogenesis and accelerate tumor growth.Quantification of VEGF in esophagus tissues may provide a valuable marker for prognosis and biological treatment of patients with esophageal carcinomas.

关 键 词：食管癌 免疫组织化学 肿瘤血管生成 VEGF MVD 

分 类 号：R735.1[医药卫生—肿瘤]