赤芍煎剂对重症急性胰腺炎腹腔内高压的影响  

Effects of red peony root decoction on intra-abdominal hypertension in severe acute pancreatitis

作　　者：谢飚[1] 贾林[1] 平丽[1] 黄耀星[1] 吴琼[1] 周妙英[1] 

机构地区：[1]广州医学院附属广州市第一人民医院消化内科,广东广州510180

出　　处：《广州医学院学报》2013年第3期57-59,共3页Academic Journal of Guangzhou Medical College

基　　金：广东省中医药局科研课题(2010016)

摘　　要：目的:探讨赤芍煎剂对重症急性胰腺炎(SAP)相关腹腔内高压(IAH)的疗效及其抗炎机制。方法:完全随机将39例重症急性胰腺炎患者分为常规治疗组(19例)和赤芍煎剂治疗组(20例),观察两组患者治疗前后(0、1、7、14d)腹腔内压力(IAP)、血清TNF-α及IL-6的变化。结果:两组治疗后IAP、血清TNF-α及IL-6水平较入院时下降,其中以赤芍煎剂治疗组下降最明显(P<0.05);结论:赤芍煎剂可能通过清除血清炎性介质而明显降低SAP患者腹腔内压力。Objectlve： To investigate the effects of red peony root decoction （ RPRD ） on intra-abdominal hypertension in patients with sever acute pancreatitis （SAP） and the associated anti-inflammatory mechanisms. Methods： Thirty-nine patients with SAP were randomly assigned to conventional treatment group （n = 19 ）and RPRD treatment group（ n =20）. This was followed by determination of changes in the levels of intra-abdominal pressure（IAP） ,tumor necrosis factor-or （TNF-ct） and interleukin-6 （ IL-6 ） at days 0, 1,7 and 14, respectively. Results：Both groups, particularly the PRPD treatment group, evidenced a remarkable reduction in the levels of IAP,TNF-α and IL-6 compared with those on admission （all P 〈 0.05 ）. Conclusion： RPRD may significantly reduce IAP via elimination of inflammatory mediators in patients with SAP.

关 键 词：重症急性胰腺炎 腹腔内高压 炎性介质 

分 类 号：R576[医药卫生—消化系统]