CE化疗与选择性支气管动脉灌注MFP治疗非小细胞肺癌  

OBSERVATION ON THERAPEUTIC EFFECTS OF ALTERNATIVE BRONCHUS ARTERIO-PERFUSION MFP AND CE GENERAL CHEMOTHERAPY IN PATIENTS WITH NSCLC

作　　者：李长生[1] 高建飞[2] 李清泉[1] 潘显光[1] 

机构地区：[1]湖北医科大学第一附属医院呼吸科,武汉430060 [2]广州军区武汉总医院肿瘤科

出　　处：《肿瘤》2000年第6期435-437,共3页Tumor

摘　　要：目的　观察选择性经支气管动脉灌注 MFP和全身外周静脉给予 CE化疗交替治疗非小细胞肺癌 (NSCL C)的疗效。方法　 34例 NSCL C患者第 1、3周期用 CE方案 ,第 2、4周期用 MFP,共行 91周期化疗 ,每例均完成 2周期以上化疗。并与同期仅作全身 CE化疗的 34例 NSCL C患者进行对照。结果　观察组完全缓解 (CR) 4例 (11.8% ) ,部分缓解 (PR) 18例 (5 2 .9% ) ,总有效率为 6 4.7% ,均明显高于对照组 (P<0 .0 1)。主要毒副作用为骨髓抑制、胃肠道反应、脱发、低热和头痛等。结论　经支气管动脉灌注 MFP与外周静脉给予 CE交替化疗 ,是治疗 NSCL C的一种有效率较高。Objective To observe the therapeutic effects of alternative use of selective transarterial infusion of MFP and systemic peripheral venous instillation of CE chemotherapy in the treatment of non-small-cell lung cancers(NSCLC).Methods 34 cases of NSCLC received CE chemotherapy in the 1st and 3rd cycles and MFP arterial infusion in the 2nd and 4th cycles. Altogather 91 cycles were used and each case received 2 cycles at least. During the same period of time, 34 cases of NSCLC received CE chemotherapy alone were used as control group.Results In the treatment group, 4 cases (11.8%) of complete response (CR) and 18 cases (52.9%) of partial respone (PR) and both were much higher than those in control group ( P <0 01). Bone marrow depression, gastro-intestinal reactions, alopecia,low grade fever and headache were the main side effects.Conclusion The alternative use of intra-arterial MFP and systemic CE chemotherapy in treating NSCLC has a higher therapeutic effect and the side reactions were tolerable.

关 键 词：非小细胞肺癌 CE化疗 支气管动脉灌注 MFP 

分 类 号：R734.205[医药卫生—肿瘤]