树突状细胞在维吾尔族宫颈癌中的临床病理特征及意义  

The clinical pathological features and significance of DC in cervical cancer in Uighur

作　　者：刘迎嘉[1] 张晨[1] 

机构地区：[1]新疆医科大学第五附属医院,新疆乌鲁木齐830011

出　　处：《中国实用医药》2013年第28期12-13,共2页China Practical Medicine

基　　金：新疆医科大学科研创新基金(项目编号:XJC201074)

摘　　要：目的研究宫颈正常组织、慢性炎症、宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)组织、宫颈癌中树突状细胞(dendritic cells,DC)分布变化,探讨肿瘤局部免疫功能状态。方法应用免疫组化S-P法检测正常宫颈、慢性炎症、CIN组织及宫颈癌中的DC形态分布特征。结果宫颈癌组中DC高度浸润13例,低度浸润27例;CIN组中高度浸润24例,低度浸润6例;慢性炎症组中高度浸润11例,低度浸润4例;正常对照组中高度浸润10例,低度浸润5例。CIN组的DC高度浸润率高于宫颈癌组和正常对照组,相比差异有统计学意义(P<0.05),CIN组与炎症组DC高度浸润率相比差异无统计学意义(P>0.05)。宫颈癌组DC高度浸润率小于正常对照组和炎症组,差异有统计学意义(P<0.05)。结论 DC在子宫颈癌的发生、发展中起着重要的作用,反映肿瘤局部的免疫状态,为宫颈癌预后的判断和生物治疗提供实验依据。Objective To study the infiltrating degree and distributing of dendritic cells（DC） in uterine cervical tissue, and the relation between them, to discuss the immune function of local tumor.Methods Normal uterine cervix, inflammatory uterine cervix, CIN and of cervical carcinoma were identified the expression of DC by immunehistochemical method（S-P）.Results The infiltrating degree of DC in epithelial CIN was higher than that in normal uterine and cervical carcinoma, their difference had statistic significance（P〈0.05）, the difference in the CIN and inflammatory cervix had no statistic significance（P〈0.05）.Conclusion DC react on the pathogenesis and development of cervical squmous carcinoma, provide experiment there under to prognosis and biological treatment in cervical carcinoma.

关 键 词：子宫颈癌 树突状细胞 免疫组化 维吾尔族 

分 类 号：R737.33[医药卫生—肿瘤]