经肝动脉化疗栓塞联合射频消融治疗肝细胞癌疗效荟萃分析  

Transcatheter arterial chemoembolization combined with radiofrequency ablation for the treatment of hepatocellular carcinoma: a systematic review and Meta analysis

作　　者：赵松[1] 陈学春 龙清云[1] 张晓龙[1] 

机构地区：[1]不详430071武汉大学中南医院介入放射科 [2]湖北孝感市第一人民医院

出　　处：《介入放射学杂志》2013年第11期908-913,共6页Journal of Interventional Radiology

摘　　要：目的探讨经肝动脉化疗栓塞(TACE)联合射频消融(RFA)与单独TACE或RFA对肝细胞癌(HCC)治疗的临床疗效比较。方法通过计算机检索或手工收集近期国内外关于TACE联合RFA疗法与TACE或RFA单独治疗HCC效果对比的文献,对符合分析条件的21篇文献录入分析,重点比较患者术后生存率及复发率。结果与单独治疗组相比,联合治疗组1、2、3年生存率高,肿瘤复发率低,组间差异均有统计学意义(P<0.01)。数据敏感性分析显示,联合组无论1、2、3年生存率还是复发率均优于TACE或RFA组(P<0.01)。联合组1年生存率及局部复发率优于RFA组,且差异有统计学意义(P<0.05),而2年生存率组间差异无统计学意义(P=0.05)。结论 TACE联合RFA对于HCC治疗效果要优于TACE或RFA单独治疗,可有效提高患者生存期及降低肿瘤复发率。Objective To compare the clinical efficacy of transcatheter arterial chemoembolization （TACE） combined with radiofrequeney ablation （RFA） with that of pure TACE or pure RFA in treating hcpatocellular carcinoma （HCC）. Methods The medical literatures recently published at home and abroad concerning the clinical results of TACE ＋ RFA, simple TACE and simple RFA in treating HCC were collected through electronic or manual searching. A total of 21 academic papers were enrolled in this study. The postoperative survival rate and recurrence were analyzed and compared between different therapies. Results The 1 -year, 2-year and 3-year survival rates of TACE ＋ RFA combination group were significantly higher than those of simple TACE group and simple RFA group （P 〈 0.01 ）. Besides, the recurrence rate of TACE ＋ RFA combination group was significantly lower than that of simple TACE group and simple RFA group （P 〈 0.01 ）. Analysis of data sensitivity showed that 1-year, 2-year and 3-year survival rates as well as the recurrence rate of TACE ＋ RFA combination group were superior to those of TACE subgroup （P 〈 0.01 ）, and 1 -year survival rate as well as the local recurrence rate of TACE ＋ RFA combination group were superior to those of RFA subgroup （P 〈 0.01 ） although no significant difference in 2-year survival rate existed between TACE ＋ RFA combination group and RFA subgroup （P = 0.05）. Conclusion TACE combined with RFA therapy is superior to simple TACE and simple RFA in treating HCC. The combination use of TACE and RFA can effectively increase the survival time and reduce the recurrence of the tumor.

关 键 词：肝细胞癌 经肝动脉化疗栓塞 射频消融 荟萃分析 

分 类 号：R735.7[医药卫生—肿瘤]