HDGF和ADAM9在食管癌中的异常表达及意义  

The expression and significance of HDGF and ADAM9 in esophageal cancer

作　　者：徐统震[1] 孙雪飞[1] 栾子营[1] 杨国涛[1] 

机构地区：[1]山东大学齐鲁医院胸外科,济南250012

出　　处：《中华胸心血管外科杂志》2013年第10期610-613,共4页Chinese Journal of Thoracic and Cardiovascular Surgery

摘　　要：目的探讨肝癌衍生生长因子（HDGF）以及去整合素-金属蛋白酶9（ADAM9）在食管癌中的表达及其与临床病理特征和预后的关系。方法采用免疫组织化学sP法，检测113例食管癌及10例正常食管黏膜组织（对照组）中HDGF和ADAM9的表达。结果免疫组化结果显示，HDGF和AD-AM9在食管癌组织中的阳性表达率分别为78．8％和68．1％，明显高于正常食管黏膜组织（均为30％）。食管癌组织中ADAM9的表达与患者的肿瘤分化程度、PT分期以及术后5年生存率密切相关，差异均有统计学意义（P〈0．05），与患者的性别、年龄、肿瘤的组织类型、肿瘤部位以及大小无关（P〉0．05）；HDGF则只与肿瘤的胛分期密切相关，差异均有统计学意义（P〈0．05），与其余因素无明显密切关系（P〉0．05）。另外，两者在食管癌中的表达呈线性相关性。结论HDGF和ADAM9对肿瘤的发生发展以及侵袭转移发挥重要作用，加强两者的联合检测可以作为食管癌患者靶向治疗及术后判断预后的指标。Objective To explore the expression and significance of HDGF and ADAM9 in esophageal cancer. Methods HDGF and ADAM9 expression in 113 patients with esophageal cancer （78 males and 35 females） with ages ranging from 28 to 87 years, averaged （61.2 ± 8.6） years, were analyzed by SP immunohistoehemical staining. Results The positive rates of HDGF and ADAM9 in esophageal cancer （78.8% and 68.1% respectively） were significantly higher than those in normal tissue（ all were 30% ）. ADAM expressions were not correlated with age, sex, tissue types, lymph nodes metastasis, lo- cation and tumor size （P 〉0.05） ;the positive expression rate of HDGF and ADAM9 was related to differentiation, PT stages, and 5-year survival rate （P 〈 0.05 ）. HDGF was correlated with PT stage. Conclusion The expressions of HDGF and AD- AM9 in esophageal cancer tissues were more higher than normal esophageal tissues, this means they could promote the develop- ment of tumor cells transformation, multiple and moving, and may be an useful tool for providing information about the targeted therapy and prognosis.

关 键 词：食管肿瘤 肝癌衍生生长因子 去整合素-金属蛋白酶9 预后 

分 类 号：R735.1[医药卫生—肿瘤]