DKK1、SFRP4和Wnt1在宫颈鳞癌中的表达及意义  

The Expression and Clinical Significance of DKK1, SFRP4 and Wnt1 in Cervical Squamous Cell Carcinoma

作　　者：侯安丽[1] 李秀芬[1] 张雅丽[1] 杨冬蕊[1] 苏晓霞[1] 

机构地区：[1]承德医学院附属医院妇科,067000

出　　处：《天津医药》2013年第11期1070-1072,I0003,共4页Tianjin Medical Journal

摘　　要：目的研究Wnt信号通路抑制因子DKK1、分泌型卷曲相关蛋白(SFRP)4及Wnt基因家族因子(Wnt1)在宫颈鳞癌中的表达及其临床意义。方法 76例宫颈癌患者病理标本为SCC组,36例子宫良性肿瘤切除标本为对照组(NC组),应用免疫组化法检测DKK1、SFRP4及Wnt1在SCC组及NC组中的表达。结果 DKK1在SCC组的表达低于NC组(P<0.05)。SFRP4及Wnt1在SCC组的表达均高于NC组(P<0.05)。DKK1、SFRP4及Wnt1在不同临床病理分期、组织分化程度、肿瘤大小及有无淋巴结转移SCC患者间表达差异有统计学意义(均P<0.05)。宫颈鳞癌中DKK1与SFRP4、Wnt1的表达均呈负相关(均P<0.05),SFRP4与Wnt1在宫颈鳞癌中的表达呈正相关(P<0.05)。结论 SFRP4和Wnt1在宫颈鳞癌的发生中可能存在协同作用,而DKK1可能作为宫颈鳞癌的抑制因子发挥作用。Objective To investigate the expressions of DKK1,SFRP4 and Wntl in cervical squamous cell carcino- ma（SCC）, and the clinical significance thereof. Methods There were 76 samples of cervical squamous cell carcinoma were included in SCC group and 36 benign uterine resection specimens were control group （NC）. The immunohistochemical meth- od was applied to detect the expressions of DKK1, SFRP4 and Wntl in two groups. Results The expression of DKK1 was significantly lower in SCC group than that in NC group （P 〈 0.05）. The expression levels of SFRP4 and Wntl were significant- ly higher in SCC group than those of NC group （P 〈 0.05）. There were significant differences in the expressions of DKK 1, SFRP4 and Wntl between samples of different clinical staging, differentiation, sizes of tumor and lymph node metastasis （P 〈 0.05）. The expression of DKK1 was negatively correlated with SFRP4 and Wntl in SCC group （P〈 0.05）. The expression of SFRP4 was positively correlated with Wntl in SCC group （P 〈 0.05）. Conclusion The roles of SFRP4 and Wntl are syn- ergistic interactions in the development of SCC. DKK 1 is an inhibiting factor of SCC.

关 键 词：宫颈肿瘤 癌  鳞状细胞 Wnt1蛋白质 免疫组织化学 DKK1 分泌型卷曲相关蛋白 

分 类 号：R735.7[医药卫生—肿瘤]