关于肿瘤细胞周期与凋亡的商榷  

A discussion on proliferation cycle and apoptosis of tumor cells

作　　者：刘宏颀[1] 

机构地区：[1]第四军医大学基础医学院细胞生物学教研室,陕西西安710032

出　　处：《医学争鸣》2013年第5期13-14,共2页Negative

摘　　要：肿瘤的生长涉及多方面的因素,其中增殖和凋亡是主要的判定指标。本文从五个方面对《医学争鸣》2012年第3期《肿瘤细胞周期的长与短及凋亡的多与少——肿瘤生长的定律》一文进行了商榷。其一,肿瘤具有细胞增殖的不均一性;其二,细胞自噬与肿瘤的凋亡关系密切;其三,肿瘤干细胞的作用不能低估;其四,肿瘤细胞群体中终末分化细胞也影响肿瘤生长;其五,理论公式在充分证实前宜称假说,并对原肿瘤生长公式进行了补充和完善。Tumor growth involves various factors, of which the main one is cell proliferation and apoptosis. This article suggests five discussible viewpoints pertaining to a paper titled ＂Length of cell cycle and amount of apoptosis in tumor cells law of the tumor growth＂ published in Negative of the 3rd issue, 2012. First, tumor has nonuniformity of cell proliferation; Second, autophagy has a tight relation with tumor cell apoptosis; Third, the role of tumor stern cell can not be underestimated; Fourth, terminally differentiated cells also affect tumor growth in tumor cell mass; Fifth, theoretical formula should be termed hypothesis before it has been fully confirmed. At tast, the original tumor growth formula is supplemented and amended.

关 键 词：肿瘤 细胞周期 凋亡 商榷 

分 类 号：R73[医药卫生—肿瘤]