ST13和HSP70在胃息肉及胃癌中的表达及相关性  

Expression of ST13 and HSP70 in gastric polyps and gastric cancer

作　　者：陈吉[1] 牛昊书[1] 

机构地区：[1]内蒙古包钢医院消化内科,内蒙古自治区包头市014010

出　　处：《世界华人消化杂志》2013年第29期3059-3066,共8页World Chinese Journal of Digestology

基　　金：内蒙古自然科学基金面上资助项目;No.2013MS1104~~

摘　　要：目的:测定肿瘤发生抑制基因1 3号(suppression of tumorigenicity 13,ST13)蛋白和热休克蛋白70(heat shock protein 70,HSP70)在胃息肉癌变过程中的表达水平,揭示ST13和HSP70在胃息肉及胃癌形成过程中的的相互关系及临床意义.方法:采用免疫组织化学SABC法检测ST13和HSP70在106例胃黏膜组织中的表达水平,按组织病理类型分为:正常胃黏膜组30例、增生性息肉组30例、腺瘤样息肉组16例、胃癌组30例,研究二者在胃息肉癌变过程中表达的相互作用及临床意义.结果:采用Krusral-wallis H方法检验HSP70在正常胃黏膜组、增生性息肉组、腺瘤样息肉组、胃癌组中的表达秩均值分别为32.35、40.47、63.25、82.48,有非常显著的差异性(P<0.01),表达呈逐渐递增趋势.ST13在正常胃黏膜、增生性息肉、腺瘤样息肉、胃癌组织中的表达秩均值分别为68.25、59.77、44.91、37.07,有非常显著差异性(P<0.01),表达呈逐渐递减趋势.HSP70和ST13在腺瘤样息肉组和胃癌组中表达呈非常显著负相关(P<0.01).结论:(1)HSP70蛋白在正常胃黏膜、胃增生性息肉、胃腺瘤样息肉、胃癌组织中的表达水平呈显著增高趋势;(2)ST13蛋白在正常胃黏膜、胃增生性息肉、胃腺瘤样息肉、胃癌组织中的表达水平呈显著降低趋势;(3)在胃腺瘤样息肉及胃癌组织中HSP70蛋白与ST13蛋白可能相互作用,其相互关系为负相关,HSP70蛋白可能对其分子共伴侣ST13蛋白产生直接或间接下调作用.AIM： To detect the expression of suppression of tumorigenicity13 （ST13） and heat shock protein70 （HSP70） in gastric polyps and gastric cancer and to analyze their correlation. METHODS： Immunohistochemistry was used to detect the expression of ST13 and HSP70 in 30 cases of normal gastric mucosa, 30 cases of gastric polyps, 16 cases of gastric adenomatous polyps, and 30 cases of gastric carcinoma. The correlation between expression of ST13 and HSP70 in gastric polyps and gastric carcinoma was analyzed. RESULTS： The rank mean for HSP70 expression in normal gastric mucosa, hyperplastic polyps, adenomatous polyps, gastric carcinoma was 32.35, 40.47, 63.25, and 82.48, respectively, showing a gradually decreasing trend （P 〈 0.01）. The rank mean for expression of STl3 in normal gastric mucosa, hyperplastic polyps, adenomatous polyps, and gastric carcinoma group was 68.25, 59.77, 44.91 and 37.07, respectively, showing a gradually increasing trend. HSP70 and ST13 expression was negatively correlated in both adenomatous polyps and gastric cancer. CONCLUSION： HSP70 protein expression shows an increasing trend and ST13 protein expression shows a decreasing trend in gastric carcinogenesis, suggesting that HSP70 and ST13 are closely related to the formation of gastric cancer. There is a negative correlation between HSP70 protein and ST13 protein expression in gastric adenomatous polyps and gastric carcinoma, suggesting that they may interact with each other.

关 键 词：ST13 HSP70 胃息肉 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]