脑部缺血预适应的诱发因素、机制及应用前景  

Triggers,Mechanisms,and Potential Clinical Applications of Cerebral Ischemic Tolerance

作　　者：张雪[1] 虞雪融[1] 黄宇光[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院麻醉科,北京100730

出　　处：《中国医学科学院学报》2013年第5期567-570,共4页Acta Academiae Medicinae Sinicae

基　　金：卫生部卫生行业科研专项基金(201002005)~~

摘　　要：缺血预适应现象可见于机体多种脏器中,其中尤其以脑部缺血预适应现象和可能的临床应用价值最引人关注。随着多种脑部缺血预适应诱发因素的发现,相关机制研究也在不断深入。远处缺血预处理及药物诱导(如促红细胞生成素)由于其较强的临床应用可行性及安全性,可能成为未来脑部缺血预适应在人体中研究和应用的重要突破口。Ischemic tolerance exists in many organs, among which the cerebral ischemic tolerance and its potential clinical applications are most notable. The discovery of new triggers of cerebral ischemic tolerance has brought more interesting insights into the molecular mechanisms. The remote ischemic preconditioning and phar- macological induction of cerebral ischemic tolerance have shown promising clinical safety and feasibility, and therefore may be important breakthroughs in the clinical application of cerebral ischemic tolerance.

关 键 词：脑 缺血预适应 远处缺血预处理 促红细胞生成素 

分 类 号：R743[医药卫生—神经病学与精神病学]