电压-门控钠离子通道Nav1.5与肿瘤关系研究进展  

Progress of voltage-gated sodium channel Nav1.5 in tumor

作　　者：邢德广[1] 王军[1] 王运杰[1] 欧绍武[1] 丁大领[1] 管格非[1] 仇波[1] 

机构地区：[1]中国医科大学附属第一医院神经外科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2013年第11期2596-2601,共6页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:31100770)

摘　　要：Nav1.5钠离子通道是电压-门控钠离子通道的一种,研究发现Nav1.5不仅在维持正常电生理活动中扮演着重要的角色,而且其多种变构体的表达被认为是和肿瘤形成有密切关系的胚胎基因的再表达。最近的研究证明Nav1.5在人体许多肿瘤组织中的表达水平显著升高,如人脑胶质瘤、乳腺癌等。深入研究发现其在各种肿瘤细胞的增殖和迁移等过程起着重要的作用。本文将结合国内外对电压-门控Na+通道Nav1.5的最新研究进展及本小组的工作,对Nav1.5及其与相关肿瘤的关系作一综述。Nav1.5 is one of voltage-gated sodium channels.Studies have found that Nav1.5 not only play an important role in normal electrophysiological activities but also have a close relationship with tumors.The presence of various allosteric Nav1.5 is considered to be the re-expression of embryonic genes which are closely related to tumor formation.Recently,a number of studies have reported that the expression of Nav1.5 in many kinds of tumors significantly increased,such as glioma,breast cancer,etc.Furthermore,studies found that the activity of Nav1.5 could influence proliferation and migration of tumor cells.Based on the available literature and the findings of our research team,the current paper will review the relationship between the voltage-gated sodium channel Nav1.5 and tumors.

关 键 词：电压-门控钠离子通道 NAV1 5 肿瘤 

分 类 号：R730.23[医药卫生—肿瘤]