P-选择素与nm23基因蛋白在胃癌中的表达及其与肿瘤转移关系的研究  

Study on the Expression of P-selectin and nm23 Gene Protein in Gastric Cancer and Their Correlation with Tumor Metastasis

作　　者：徐玉芳[1] 宋国忠[2] 张云汉[2] 张玉昆 

机构地区：[1]河南职工医学院，郑州 450003 [2]河南医科大学

出　　处：《肿瘤防治研究》2000年第6期447-448,451,共3页Cancer Research on Prevention and Treatment

摘　　要：目的　研究P 选择素、nm2 3基因蛋白在胃癌中的表达及其与转移的关系。方法　采用免疫组织化学技术 ,对 57例胃癌及 15例正常胃组织的P 选择素及nm2 3表达情况进行观察。结果　①P 选择素、nm2 3基因的表达与胃癌组织学分级无关。②P 选择素表达在淋巴结转移组明显增强 ,在Ⅲ、Ⅳ期胃癌显著高于Ⅰ、Ⅱ期。③nm2 3基因表达与TNM分期无关 ,在淋巴结转移组中阳性率显著低于无淋巴结转移组。④P 选择素和nm2 3基因在胃癌中的表达呈显著负相关关系。结论　P 选择素高表达与nm2 3基因低表达提示胃癌浸润转移的高风险性。Objective To study the expression of P-selectin and nm23 gene protein in gastric cancar and their relation with metastasis.Methods Using immunohistochemistry technique,we have observed the expression of P-selectin and nm23 gene protein in 57 cases of gastric cancer and 15cases of normal stomach tissue.Results ① The expression of P-selectin and nm23 was not corelated with histologic grade.② The expression rates of P-selectin were higher in TNM stage Ⅲ or Ⅳ than that in stage Ⅰ or Ⅱ,which were also higher in tumor with lymphnode metastasis group than that in tumor without lymphnode metastasis group.③ The expression of nm23 was not correlated with TNM stage,and the expression rate of nm23 was lower in tumor with lymphnode metastasis group than in tumorwithout lymphnode metastasis group.④ There was a negative correlation between the expression of P-selectin and nm23 gene protein in gastric cancer.Conclusin The resuts suggest that overexpression of P-selectin and lessexpression of nm23 predict metastatic possibility in gastric cancer.

关 键 词：P-选择素 NM23基因 胃癌 肿瘤转移 表达 

分 类 号：R735.202[医药卫生—肿瘤] R73-37[医药卫生—临床医学]