nm23基因在恶性滋养细胞肿瘤中的表达及其意义  

Nm23 Gene Exproession and Its Clinical Significance in Human Malignant Trophoblastic Tumors

作　　者：熊永炎[1] 熊艳 唐志佼[3] 曾俊[1] 

机构地区：[1]湖北医科大学附属第二医院病理科，武汉 430071 [2]湖北医科大学附属第二医院肿瘤科 [3]湖北医科大学病理教研室

出　　处：《肿瘤防治研究》2000年第6期452-453,471,共3页Cancer Research on Prevention and Treatment

基　　金：湖北省教委资助

摘　　要：目的　研究nm2 3基因在恶性滋养细胞肿瘤中的表达和意义。方法　采用LSAB免疫组化染色方法 ,检测nm2 3基因在 91例恶性滋养细胞肿瘤中的表达水平。结果　nm2 3在侵袭性葡萄胎的阳性表达率 ( 10 0 % )显著高于绒毛膜癌 ( 68 63% ) (P <0 0 1)。在不同肿瘤性滋养细胞中 ,合体滋养细胞 (ST)基本不表达 ,中间型滋养细胞 (IT)和细胞滋养细胞 (CT)部分表达 ,但侵袭性葡萄胎中IT阳性表达率 ( 62 50 % )极明显高于绒毛膜癌 ( 3 92 % ) (P <0 0 1)。侵袭性葡萄胎原发瘤强阳性表达率 ( 82 76% )明显高于转移瘤 ( 2 7 2 7% ) ,原发性绒毛膜癌阳性表达率 ( 84 37% )明显高于转移性绒毛膜癌 ( 4 2 11% ) ,差异均具有高度显著性 (P <0 0 1)。结论　nm2 3基因的表达水平与恶性滋养细胞肿瘤的分化呈正相关 ,与肿瘤的转移能力呈负相关。Objective To study nm23 gene expression and its clinical significance in human malignant trophoblastic tumors (HMTT).Methods The expression of nm23 gene was studied immunohistochemically using LSAB method in 91 HMTT.Results The positive rate of nm23 gene expression in invasive mole(100%) was much more high than one in choriocarcinoma(68.63%)(p<0.01).The expression of nm23 was basically negative in neoplastic syncytiotrophoblast(ST),was partially positive in intermediate trophoblast(IT) and cytotrophoblast(CT),but positive expression rate of IT in invasive mole (62.50%) was far higher than one in choriocarcinoma (3.92%)( P <0.01).The intensive positive rate of nm23 gene of the primary tumors (82.76%)was by far higher than one of the metastatic tumors (27.27%) in invasive moles ( P <0.01).The positive expression rate of nm23 gene of the primary tumors(84.37%) was much more high than one of the metastatic tumors (42.11%) in choriocarcinoma ( P <0.01).Conclusion The expression levels of nm23 gene were strikingly correlated with tumor cell differentiation,were inversely correlated with tumor metastatic capacity in HMTT.

关 键 词：恶性滋养细胞肿瘤 基因表达 免疫组化学 

分 类 号：R737.33[医药卫生—肿瘤]