p16和ProEx C在宫颈活检低度鳞状上皮内病变中的表达及意义  

The expression of p16 and ProEx C in low-grade squamous intraepithelial lesions of cervix uteri and its clinical significance

作　　者：潘升华[1] 安慧敏[1] 吴文珍[1] 孙利敏[1] 张亮[1] 陈国荣[2] 夏康[1] 池晓萍 

机构地区：[1]温州医科大学附属第三医院病理科,浙江温州325200 [2]温州医科大学附属第一医院病理科,浙江温州325000

出　　处：《温州医学院学报》2013年第10期660-663,共4页Journal of Wenzhou Medical College

基　　金：瑞安市科技计划项目(201203083)

摘　　要：目的:探讨p16和ProEx C在宫颈活检低度鳞状上皮内病变(LSIL)中的表达及预后意义。方法:141例宫颈活检诊断LSIL的病例,包括术后诊断高度鳞状上皮内病变(HSIL)83例及LSIL 58例,用免疫组织化学EnVison法检测其p16和ProEx C的表达情况。结果:①p16在LSIL组和HSIL组中阳性率分别为25.9%(15/58)和78.3%(65/83),ProEx C在LSIL组和HSIL中阳性率分别为36.2%(21/58)和63.9%(53/83),差异均有统计学意义(P<0.01)。②当p16和ProEx C同时阳性时其特异度达87.9%,当p16和ProEx C其中之一阳性时其灵敏度达89.2%。结论:p16和ProEx C是预测HSIL的有用指标,对p16和ProEx C阳性患者应尽早手术治疗。Objective：To probe the expression and prognostic significance ofp16 and ProEx C in low-grade squamous intraepithelial lesions （LSIL） from the biopsy of cervix uteri.Methods：The expressions of p16 and ProEx C in 141 cases of LSIL from the biopsy of cervix uteri,including 83 cases of high-grade squamous intraepithelial lesion （HSIL） and 58 cases of LSIL diagnosed postoperatively,were detected with immunohistochemical EnVison method.Results：① The positive rate of p16 in LSIL and HSIL group was 25.9％ （15/58） and 78.3％ （65/83）respectively,with significant difference （P＜0.01）,the positive rate of ProEx C in LSIL and HSIL group was 36.2％ （21/58） and 63.9％ （53/83）,with significant difference （P＜0.01）.② p16 and ProEx C both positive had higher specificity （87.9％）,and one of p16 and ProEx C positive had higher sensitivity （89.2％）.Conclusion：It is suggested that p 16 and ProEx C be useful markers to predict HSIL,patients with positive expression of p 16 and ProEx C should be received operation as early as possible.

关 键 词：宫颈上皮内瘤变 宫颈鳞状上皮内病变 P16 ProEx C 

分 类 号：R737.3[医药卫生—肿瘤]