慢性应激抑郁模型大鼠左右大脑化学发光强度不对称性改变  

Asymmetrical changes of chemiluminescence intensities between left brain and right brain of chronic--mild--stress and depression--model rats

作　　者：窦立敏[1] 吴鹤鸣[1] 王东[1] 

机构地区：[1]南京医科大学附属南京市江宁医院神经外科,211100

出　　处：《神经疾病与精神卫生》2013年第4期358-360,共3页Journal of Neuroscience and Mental Health

摘　　要：目的检测抑郁大鼠模型左右海马、额叶、颞叶化学发光强度的改变，探讨抑郁症大鼠大脑不对称性损伤的可能机制。方法建立大鼠慢性应激抑郁模型，采用过氧化氢诱导化学发光法观察大鼠海马、额叶、颞叶组织的化学发光强度。结果抑郁模型大鼠左侧海马、颞叶、额叶化学发光强度值均高于正常对照组，差异有统计学意义[海马：（84．17±4．22）VS（65．67±10．44）；额叶：（157．33±9．3]）VS（123．00±8．34）；颞叶：（153．67±11．96）VS（120．17±9．35）；t分别为～6．893，-10．600，r-6．144；P〈0．051]l，而右侧海马、额叶、颞叶组织化学发光强度的比较差异无统计学意义（P〉0．05）。结论抑郁症对大鼠大脑组织的损伤存在自由基生成和脂质过氧化反应不对称性改变。Objective To investigate the effects of depression on the changes of chemiluminescence intensities of hippocampus, [rontal cortex, temporal cortex, and discuss the potential mechanism of the asymmetrical injuries in depressed rats. Methods After having established the chronic--mild--stress and depression--model, the chemiluminescence intensities in hippoeampus, frontal cortex, and temporal cor- tex of model rats were observed by hydrogen peroxide in＆iced chemiluminescence analysis method. Re- suits The chemiluminescence intensities in the left hippocampus, frontal cortex, temporal cortex signifi- cantly changed in depressed rats compared with normal control group[hippocampus： （65.67 ± 10.44） vs （84.17±4.22）; frontal cortex： （123.00±8.34） vs （157.33±9.31）; temporal cortex： （120. 17±9.35） vs （153.67±11.96） ; P-Q0.05）], which had the statistical significance. There were no significant chan- ges in the right side （P） 0.05）. Conclusions The injuries of brain tissues in the chronic mild stressed rats were asymmetrical including the generation of free radicals and lipid leroxidation.

关 键 词：抑郁症 慢性应激 化学发光 不对称性 

分 类 号：R749.41[医药卫生—神经病学与精神病学]