白介素12基因多态性与恶性肿瘤易患性的病例对照研究Meta分析  

Association between Interleukin-12 Gene Polymorphisms and Cancer Susceptibility: A Meta-analysis of Case-control Studies

作　　者：张雄 金粉淑 张立国 陈瑞雪 赵金慧 王雁楠 王恩富 姜振东 

机构地区：[1]湖北省武昌医院检验科,湖北省武汉市430063

出　　处：《中国全科医学》2013年第30期3533-3538,共6页Chinese General Practice

摘　　要：目的评价白介素12(IL-12)基因多态性与恶性肿瘤易患性的关联。方法计算机检索PubMed、Embase、Web of Science、CBM、万方、维普、中国知网(CNKI)等数据库(时间为1998年1月—2013年1月)有关IL-12基因多态性与恶性肿瘤易患性关联的病例对照研究。采用STATA 12.0软件进行Meta分析,计算相对危险度(RR)及其95%可信区间(CI)来描述关联。结果 18项病例对照研究符合纳入标准,包括6 463例恶性肿瘤患者和7 412例健康对照者。Meta分析结果表明:IL-12B基因的3'UTR A>C多态性与恶性肿瘤易患性增加有关联〔C vs.A:RR=1.06,95%CI(1.03,1.10),P<0.001;CA+CC vs.AA:RR=1.05,95%CI(1.02,1.08),P=0.001〕;而IL-12A基因的3'UTR G>A、IVS2 T>A和5'UTR T>G多态性与恶性肿瘤易患性无关联(均P>0.05)。亚组分析表明,IL-12B基因的3'UTR A>C多态性可能增加亚洲人群恶性肿瘤易患性〔C vs.A:RR=1.04,95%CI(1.01,1.08),P=0.017;CA+CC vs.AA:RR=1.04,95%CI(1.01,1.07),P=0.018〕,尤其是宫颈癌〔C vs.A:RR=1.11,95%CI(1.01,1.22),P=0.032;CA+CC vs.AA:RR=1.10,95%CI(1.10,1.19),P=0.023〕和鼻咽癌〔C vs.A:RR=1.28,95%CI(1.16,1.40),P<0.001;CA+CC vs.AA:RR=1.24,95%CI(1.15,1.35),P<0.001〕。结论 IL-12B基因3'UTR A>C多态性可能是亚洲人群宫颈癌和鼻咽癌易患性增加的危险因素。Objective To investigate the association between the interleukin -12 （IL- 12） gene polymorphisms and cancer risk. Methods PubMed, Embase, Web of Science, CBM, Wanfang, VIP and CNKI databases were searched （January 1998 to January 2013） for all articles published that addressed IL - 12 gene polymorphisms and cancer risk. Meta - analysis was performed by using STATA 12.0 software. Results were described as relative risk （RR） with 95% confidence intervals （CI）. Results 18 case - control studies were included with a total of 6 463 cancer cases and 7 412 healthy controls. It was found that the 3＇UTR A 〉 C polymorphism of IL- 12B gene was associated with significantly increased overall risk of cancers by using ran- domeffeets model （C vs.A： RR=I.06, 95%C1 （1.03, 1.10）, P〈0.001; CA＋CC vs. AA： RR=I.05, 95%CI （ 1.02, 1.08）, P = 0. 001] . However, the 3＇UTR G 〉 A, IVS2 T 〉 A and 5＇UTR T 〉 G polymorphisms of IL - 12A gene did not appear to have an influence on cancer susceptibility （all P 〉 0.05） . Further subgroup analyses showed that the 3＇UTR A 〉 C polymorphism of IL - 12B gene was associated with increased cancer risks in the subgroups of Asians [ C vs. A： RR = 1.04, 95%CI （1.01, 1.08）, P=0.017; CA＋CCvs. AA： RR=I.（M, 95%CI （1.01, 1.07）, P=O. 018~, especially cervical cancer [Cvs. A： RR=I. ll, 95%CI （1.01, 1.22）, P=0.032; CA＋CC vs. AA： RR=I. IO, 95%CI （1.10, 1.19）, P=0.023] and nasopharyngeal cancer [C vs. A： RR=l.28, 95%CI （1.16, 1.40）, P〈0.001; CA ＋CC vs. AA： RR= 1.24, 95% CI （ 1.51, 1.35）, P 〈 0. 001 ~ , Conclusion The 3＇UTR A 〉 C polymorphism of IL - 12B gene might be a potential biomarker for cervical and nasopharyngeal cancers among Asian populations.

关 键 词：白介素12 多态性 单核苷酸 肿瘤 疾病易感性 META分析 

分 类 号：R73[医药卫生—肿瘤]