SD大鼠血小板聚集实验测定方法的研究  

Platelet Aggregation Test in SD Rats

作　　者：尹小明[1] 赵诗云[2] 彭旦明[2] 饶丽华 

机构地区：[1]江西省人民医院检验科,南昌330006 [2]江西省中医药研究院中药研究所,南昌330077 [3]南昌市中西医结合医院检验科,南昌330003

出　　处：《南昌大学学报（医学版）》2013年第8期6-7,11,共3页Journal of Nanchang University：Medical Sciences

基　　金：江西省卫生厅中医药科研基金资助项目(2008Z0047)

摘　　要：目的建立SD大鼠血小板聚集实验的测定方法。方法用二磷酸腺苷（ADP）诱导大鼠的血小板聚集,测定其5min最大聚集率。结果 SD大鼠5min由ADP诱导的血小板最大聚集率95%可信区间为52%~76%。结论 SD大鼠的血小板聚集实验方法是一种快捷、有效、稳定性、重复性好的评价药效的方法。Objective To establish a method for platelet aggregation test in SD rats.Methods Platelet aggregation was induced by ADP and 5minute maximum aggregation rate was measured in SD rats.Results The 95% confidence interval for 5minute maximum aggregation rate was 52%~76%.Conclusion The established platelet aggregation test is a quick,effective,stable and reproducible method for evaluating the pharmacological effect in SD rats.

关 键 词：SD大鼠 血小板聚集率 二磷酸腺苷 

分 类 号：R-332[医药卫生]