Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome  

作　　者：Xiaolan Su Yanping Tang Jing Zhang Yuebin Dong Wei Wei Yibing Bai Yong Liu 

机构地区：[1]Department of Gastroenterology,Wangjing Hospital of China Academy of Traditional Chinese Medicine [2]Department of Gastroenterology, Tianjin Nankai Hospital [3]Department of Gastroen-terology, Xuanwu Hospital of Traditional Chinese Medicine [4]Department of Gastroenterology, Shanghai Seventh People's Hospital

出　　处：《Journal of Traditional Chinese Medicine》2013年第5期615-619,共5页中医杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81072800)

摘　　要：OBJECTIVE:To observe the curative effect of a recipe for warming the kidney and fortifying the spleen on diarrhea-predominant irritable bowel syndrome(IBS-D).METHODS:This multi-center,double-blind,randomized,and controlled trial included 240 patients that met the inclusion criterion and were then divided into two groups of 120.Patients in the treatment group(group A)took modified Sishen Wan orally for warming the kidney and fortifying the spleen and patients in the control group(group B)took a placebo,Chao Maiya,for 4 weeks.28 days after withdrawal,there was a 6-month follow-up to observe patient recurrence condition.The total effective rate,curative effect,and recurrence rate were evaluated after treatment.RESULTS:There was statistical difference(P<0.01)between the two groups in total effective rate(92.24%in the treatment group and 49.07%in the control group),in curative effect of TCM syndrome(90.52%and 47.22%,respectively),and in the recurrence rate(15.79%and 56.86%,respectively)within6 months after treatment.CONCLUSION:Modified Sishen Wan,for warming the kidney and fortifying the spleen,can effectively treat IBS-D and better control its recurrence.OBJECTIVE： To observe the curative effect of a recipe for warming the kidney and fortifying the spleen on diarrhea-predominant irritable bowel syndrome（IBS-D）.METHODS： This multi-center, double-blind, randomized, and controlled trial included 240 patients that met the inclusion criterion and were then divided into two groups of 120. Patients in the treatment group（group A） took modified Sishen Wan orally for warming the kidney and fortifying the spleen and patients in the control group（group B）took a placebo, Chao Maiya, for 4 weeks. 28 days after withdrawal, there was a 6-month follow-up to observe patient recurrence condition. The total effective rate, curative effect, and recurrence rate were evaluated after treatment.RESULTS： There was statistical difference（P0.01）between the two groups in total effective rate（92.24% in the treatment group and 49.07% in the control group）, in curative effect of TCM syndrome（90.52% and 47.22%, respectively）, and in the recurrence rate（15.79% and 56.86%, respectively） within6 months after treatment.CONCLUSION： Modified Sishen Wan, for warming the kidney and fortifying the spleen, can effectively treat IBS-D and better control its recurrence.

关 键 词：Irritable bowel syndrome Medicine Chinese traditional Warming kidney and fortifying splee 

分 类 号：R574[医药卫生—消化系统]