氟比洛芬酯治疗骨转移癌痛患者爆发痛的效果  

Efficacy of flurbiprofen axetil for treatment of break-through pain in patients with metastatic bone cancer pain

作　　者：王昆[1] 郝建磊[1] 邵月娟[1] 成宪江[1] 管冰清[1] 闫哲[1] 

机构地区：[1]天津医科大学肿瘤医院疼痛治疗科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室,300060

出　　处：《中华麻醉学杂志》2013年第8期913-915,共3页Chinese Journal of Anesthesiology

摘　　要：目的 评价氟比洛芬酯用于骨转移癌痛患者爆发痛（BTP）治疗的效果.方法 骨转移癌痛并发BTP患者97例,采用随机数字表法,将其分为2组：吗啡组（M组,n=51）和氟比洛芬酯组（F组,n=46）.M组口服速释吗啡,单次挽救剂量为每日缓释剂量的10％ ～ 15％,重复给药,直至控制BTP;F组静脉输注氟比洛芬酯,单次剂量50 mg,给药时间30 min,最大剂量150 mg.记录治疗BTP首次起效时间及随后1个月内BTP发生频率.记录患者口服治疗背景痛药物用量及不良反应的发生情况.结果 与M组比较,F组治疗BTP首次起效时间缩短及便秘发生率降低（P＜0.05）,BTP发生频率差异无统计学意义（P＞0.05）.与BTP治疗前比较,治疗后M组背景痛治疗药物用量显著性增加（P＜0.05）,F组差异无统计学意义（P＞0.05）.结论 与速释吗啡相比,氟比洛芬酯用于骨转移痛患者BTP的治疗更安全有效,且对治疗背景癌痛药物的耐受性无明显影响.Objective To evaluate the efficacy of flurbiprofen axetil for treatment of break-through pain （BTP） in patients with metastatic bone cancer pain.Methods Ninety-seven patients with metastatic bone cancer pain complicated with BTP were randomly divided into morphine group （M group,n =51） and flurbiprofen axetil group （F group,n =46）.In group M,immediate release morphine sulfate was given orally,and the single dose for pain relief was about 10％ to 15％ of the daily slow-release dose,and the administration was repeated until BTP was relieved.In group F,flurbiprofen axetil 50 mg was infused intravenously over 30 min,and the maximum dose was 150 mg.The BTP frequency was recorded within one month after the first BTP relief.The drug consump-tion for treatment of primary cancer pain,and adverse reaction were recorded.Results The onset time of flurbiprofen axetil and immediate release morphine sulfate was （18± 9） and （35± 11） min,respectively （P ＜ 0.05）.The onset time of BTP treatment was significantly shorter,and the incidence of constipation was lower in group F than in group M （P ＜ 0.05）.There was no statistical significance in the BTP frequency between the two groups （P ＞ 0.05）.As compared with that before BTP treatment,the drug consumption for treatment of primary cancer pain was significantly increased after treatment in group M （P ＜ 0.05） and no significant changes were found after treatment in group F （P ＞ 0.05）.Conclusion Flurbiprofen axetil is safer and more effective in relieving BTP in patients with metastatic bone cancer pain than immediate release morphine sulfate,and it does not affect the drug tolerance for treatment of primary pain.

关 键 词：氟比洛芬 吗啡 肿瘤 骨转移 爆发痛 

分 类 号：R738.1[医药卫生—肿瘤]