Ⅰ型胶原吡啶交联终肽在结肠肿瘤诊断中的应用  

Investigation of pyridinolne cross linked carboxyterminal telopeptide of type Ⅰ collagen on carcinomaofrectum

作　　者：丁敏勇[1] 梅祎军[1] 周子花[1] 毛茅[1] 李春孟[1] 王理富[1] 

机构地区：[1]浙江省丽水市人民医院普外科,323000

出　　处：《中华实验外科杂志》2013年第10期2206-2208,共3页Chinese Journal of Experimental Surgery

摘　　要：目的 检测良性结肠肿瘤、恶性结肠肿瘤患者及健康对照组血清中的Ⅰ型胶原吡啶交联终肽（ICTP）活性,探讨ICTP在良恶性结肠肿瘤诊断和鉴别诊断中的价值.方法 选取75例恶性胃肠肿瘤患者,设为A组,其中71例为原发性恶性结肠肿瘤、4例为转移性肿瘤患者,另选43例良性结肠肿瘤患者为B组,同时,设52例同龄健康人为C组,均采用酶免疫测定（EIA）方法测定血清中的ICTP活性.结果 B组患者血清ICTP活性为（6.75 ±3.34） μg/L,C组血清ICTP活性为（4.68±2.91） μg/L,A组患者血清ICTP活性为（14.84±8.49） μg/L,其中,原发性恶性结肠肿瘤患者和转移性结肠肿瘤患者的血清ICTP活性分别为（17.47±10.86） μg/L和（8.14 ±5.45） μg/L.A组中两类患者的血清ICTP活性与B、C组比较差异均有统计学意义（P＜0.05）,B组患者与C组比较差异无统计学意义（P＞0.05）.而A组中原发性恶性结肠肿瘤与转移性肿瘤组之间的差异也有统计学意义（P＜0.05）.结论 血清ICTP是反映结肠肿瘤骨代谢的一个灵敏而简便的检测指标,并有助于良恶性结肠肿瘤的诊断及鉴别诊断.Objective To investigate the clinical usefulness of determination of serum pyridinoline cross linked carboxyterminal telopeptide of type Ⅰ collagen （ICTP） in patients with carcinomaofrectum.Methods 75 malignant carcinomaofrectum patients in group A with 71 primary malignant carcinomaofrecrum patients and 4 metastatic carcinomaofrectum patients were analyzed,43 benign carcinomaofrectum patients were including group B,52 normal persons were chosen in group C,Serum ICTP in everybody was determined by enzyme immunoassay （EIA）.Results The serum level of ICTP in group A was （14.84 ±8.49） μg/L,and the serum level of primary malignant carcinomaofrectum,and metastatic tumor of bone in group A were （17.47 ± 10.86） μg/L and （8.14 ± 5.45） μg/L,the serum level of ICTP in group B and C were （6.75 ±3.34） μg/L and （4.68 ±2.91） μg/L.The serum level in group A was significantly higher than that in group B and C （P ＜ 0.05）,At the same time,the serum level in primary malignant carcinomaofrectum patients were significantly higher than that of metastatic carcinomaofrectum patients （P ＜ 0.05）.Conclusion Serum ICTP was a sensitive and convenient biochemical index which could diagnose and identify carcinomaofrectum.

关 键 词：良性结肠肿瘤 恶性结肠肿瘤 转移性肿瘤 Ⅰ型胶原吡啶交联终肽 

分 类 号：R735.35[医药卫生—肿瘤]