4-甲基-2-杂环-2,3-二氢苯并[f]-1,5-硫氮杂[艹卓]-3-羧酸乙酯及其还原产物的合成、晶体结构及抑菌活性的研究  

Studies on the Synthesis,Crystal Structure and Antimicrobial Activities of 4-Methyl-2-heterocylic-2,3-dihydro-benzo[f]-1,5-thiazepine-3-carboxylic Acid Ethyl Ester and Its Reduction Products

作　　者：田克情[1] 刘晓欣[2] 薛子桥 杨田[2] 杜星琼[3] 张萍[2] 

机构地区：[1]河北化工医药职业技术学院化学与环境工程系,石家庄050026 [2]河北师范大学化学与材料科学学院,石家庄050024 [3]河北师范大学生命科学学院,石家庄050024

出　　处：《有机化学》2013年第10期2237-2243,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20972040)资助项目

摘　　要：以乙酰乙酸乙酯和含不同取代基的杂环醛为原料,经两步反应合成了一系列新颖的4-甲基-2-杂环-2,3-二氢苯并[f]-1,5-硫氮杂-3-羧酸乙酯(2a^2l),并对其中的5个化合物进行了还原,2a^2l及还原产物的结构经1H NMR IR,MS,元素分析确证.同时采用X射线衍射法测定了2a的晶体结构,2a属三斜晶系,P-1空间群.采用滤纸片法测试所合成目标化合物对枯草芽孢杆菌、白色念珠菌、标准新生隐球菌和临床新生隐球菌的抑菌活性,结果表明大部分化合物都有一定的抑菌效果,其中2a的抑菌效果尤其突出.Starting from ethyl acetoacetate and substituted heterocyclic aldehyde, a series of new 4-methyl-2-heterocyclic- 2,3-dihydro-benzo[f]-1,5-thiazepine-3-carboxylic acid ethyl esters （2a^21） were synthesized through 2-step reactions, and of which five compounds were reduced. The structures of the compounds were characterized by IH NMR, IR, MS, elemental analysis and X-ray diffraction study. The crystal of compound 2a belongs to triclinic system, space group P-1. The antibac- terical activities of the new compounds against B. subtilis, C. albicans and C. neoformans were evaluated by filter paper ap- proach, and the results indicated that most of them showed antibacterical activities, especially the compound 2a prominent.

关 键 词：1 5-苯并硫氮杂[艹卓] 杂环 还原 晶体结构 抑菌活性 

分 类 号：TQ463[化学工程—制药化工]