中国人群中亚甲基四氢叶酸还原酶C677T和A1298C基因多态性与乳腺癌相关性的Meta分析  

The correlation between the 5, 10-methylenetrahydrofolate reductase C677T or A1298C polymorphisms and breast cancer risk in China: a Meta-analysis

作　　者：宋姗姗[1] 杨博逸[1] 孙贵范[1] 

机构地区：[1]中国医科大学公共卫生学院环境与慢性病研究中心,辽宁省沈阳110000

出　　处：《中国慢性病预防与控制》2013年第5期560-564,共5页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的 研究中国人群亚甲基四氢叶酸还原酶（5,10-methylenetetrahydrofolate reductase,MTHFR）基因C677T、A1298C多态性与乳腺癌发病风险的关系.方法 检索PubMed、Embase、Cochrane图书馆、中国生物医学文献数据库（CBM）、中国期刊全文数据库（CNKI）、万方数据库,并结合文献追溯的方法,收集以中国人群为研究对象的关于MTHFR基因C677T、A1298C多态性与乳腺癌发生相关性的病例-对照研究,剔除不符合要求的文献,应用Stata 11.0软件进行Meta分析,对各项研究进行异质性检验以及计算出合并后的OR值及其95％CI.结果 共纳入15个研究,包括乳腺癌病例组3 189例,对照组4 342例,对照组人群基因型分布经检验符合H-W遗传平衡.MTHFR C677T位点TT/CC、CT/CC和TT＋CT/CC基因型与乳腺癌易感性的OR值（95％CI）分别为1.89（1.35～2.64）、1.04（0.94～1.15）和1.18（1.02～1.37）.MTHFR A1298C位点CC/AA、AC/AA和CC＋AC/AA基因型与乳腺癌易感性的OR值（95％CI）分别为1.02（0.73～1.42）、0.90（0.79～1.02）和0.91（0.81～1.03）.结论 MTHFR基因677位点C→T变异与乳腺癌的易感性相关,但仅在TT纯合子时有统计学意义.1298位点A→C变异与乳腺癌的易感性无关联.Objective To evaluate the correlation between the polymorphisms of 5, 10-methylenetrahydrofolate reductase （MTHFR） C677T, A1298C genes and risk of breast cancer in Chinese population. Methods PubMed,Embase, Cochrane Library, CBM, CNKI and Wanfang Database were searched for the case-control studies on the correlation between the two gene polymorphisms and risk of breast cancer. Unqualified studies were excluded, and the Stata 11.0 software was applied for analyzing the heterogeneity among individual studies and calculating the pooled odds ratio （OR） and 95%CI. Results In present analysis, 15 studies were included, containing the breast cancer group （3 189 cases） and the control group （4 342 subjects）, the genotypes of controls were tested, which conformed to H-W balance. The OR （95%CI） between the genotypes TT/CT, CT/CC and TT＋CT/CC at MTHFR C677T site and breast cancer risk were 1.89 （1.35-2.64）, 1.04 （0.94-1.15） and 1.18 （1.02-1.37）, respectively. The OR （95%CI） between the genotypes CC/AA, AC/AA and CC＋AC/AA at MTHFR A1298C site and breast cancer risk were 1.02 （0.73-1.42）, 0.90 （0.79-1.02） and 0.91 （0.81-1.03）, respectively. Conclusion The polymorphism （C→T） at MTHFR C677T site is correlated to the risk of breast cancer, but the polymorphism （A→C） at MTHFR A1298C site is not correlated to the risk of breast cancer.

关 键 词：乳腺癌 亚甲基四氢叶酸还原酶 基因多态性 META分析 

分 类 号：R737.9[医药卫生—肿瘤]