Yes相关蛋白基因在牙发育中的作用  

Involvement of Yes-associated protein gene in tooth development

作　　者：吕琳琳[1,2] 李纾[1,2] 

机构地区：[1]山东大学口腔医院牙周科 [2]山东省口腔生物医学重点实验室,济南250012

出　　处：《国际口腔医学杂志》2013年第6期760-763,共4页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(81271138);山东省自然科学基金资助项目(ZR2010HM050)

摘　　要：牙发育过程,包括胚胎早期预定成牙部位到发育形成完整的牙及牙周组织的发育成熟,是一个复杂的连续过程。牙发育实际上是牙源性上皮与脑神经嵴来源的牙源性间充质之间相互作用的结果,这一过程受到诸多信号的影响。Yes相关蛋白基因(YAP)是Hippo通路中的靶基因,在牙胚发育的初始阶段,可在不同部位检测到其表达。Hippo-YAP信号通路通过抑制YAP的活性,调控细胞增生和程序性细胞死亡间的平衡,从而调控器官的大小。本文就Hippo-YAP信号通路和YAP在牙发育过程中的表达等研究进展作一综述。The tooth development is a complicated process, including early embryonic tooth position, tooth formation, and periodontal tissue maturation. Tooth development is actually the result of odontogenic mesenchymal interactions of the odontogenic epithelium and cranial neural crest cells. This process is affected by various signals. Yes-associated protein gene（YAP） is the target of the Hippo pathway, which can be detected in different tissues during the initial stage of tooth development. The Hippo-YAP signaling pathway regulates the balance between cell proliferation and programmed cell death by inhibiting YAP activity, thereby regulating the size of the organ. In this paper, we summarize the recent research progress on the Hippo-YAP signaling pathway and YAP expression during tooth development.

关 键 词：Yes相关蛋白 信号转导 牙发育 

分 类 号：R78[医药卫生—口腔医学]