3种根管消毒药物治疗慢性根尖周炎的临床效果比较  

Comparison of the Antimicrobial Activity of ApexCal,Vitapex and Calcium Hydroxide as Intracanal Medicament

作　　者：张凌[1] 高景[1] 仇丽鸿[1] 

机构地区：[1]中国医科大学附属口腔医院牙体牙髓科,沈阳110002

出　　处：《中国医科大学学报》2013年第10期882-884,890,共4页Journal of China Medical University

基　　金：辽宁省科学技术计划(2011225020)

摘　　要：目的探讨ApexCal、Vitapex和氢氧化钙3种药物作为根管消毒剂对感染根管内粪肠球菌的抑制作用及对慢性根尖周炎患者的临床疗效。方法将慢性根尖周炎需行根管治疗的60例患者随机分为3组,常规清理扩大根管后,分别将ApexCa(lA组)、Vitapex(B组)糊剂、氢氧化钙(C组)糊剂置于根管内,作为消毒剂暂封,分别测定其对粪肠球菌的抑菌效果,并对患者的临床疗效进行观察和比较。结果3组封药后根管内菌量明显降低,与封药前比较差异有统计学意义(P<0.05)。A、B组封药后根管内细菌降低量较C组有统计学差异(P<0.05)。对慢性根尖周炎患者的临床疗效A、B组与C组之间具有显著差异(P<0.05)。结论 ApexCal、Vitapex可以作为有效的根管消毒剂,对慢性根尖周炎的治疗具有临床实用价值。Objective To investigate the antibacterial efficacy of ApexCal,Vitapex,and calcium hydroxide in root canal against endodontic pathogens.Methods A total of 60 patients with chronic apical periodontitis were randomly divided into 3 groups with 20 patients in each group.After regular root canal preparation,all root canals were sealed for 7 days with different root canal sealing methods using ApexCal,Vitapex,and calcium hydroxide,respectively.Enteroeoecus faecalis was assessed by real-time quantitative polymerase chain reaction before and after disinfection.The effects of root canal disinfection of 3 groups were recorded and analyzed.Results The fungus quantity in root canal was obviously reduced after the drug sealing in all the 3 groups,and the differences were statistically significant （all P 〈 0.05）.The groups of ApexCal,Vitapex performed significantly better than the calcium hydroxide group against Enterococcus faecliis （P 〈 0.05）,leading to the better clinical curative effects of patients with chronic periarthritis （P〈 0.05）.Conclusion The results supported that ApexCal and Vitapex can be used as an effective root canal disinfectant.

关 键 词：慢性根尖周炎 根管消毒药物 粪肠球菌 实时RT-PCR 

分 类 号：R781.05[医药卫生—口腔医学]