Galectin-3免疫组化检测对甲状腺滤泡性肿瘤良恶性鉴别的意义  

Galectin-3 in differential diagnosis between benign and malignant thyroid follicular tumor

作　　者：黄东航[1] 游振辉[1] 李华水[1] 张爱龙[1] 王沆[1] 邱丽贞[1] 林强[1] 

机构地区：[1]福建医科大学省立临床医学院基本外科,福州350001

出　　处：《中华内分泌外科杂志》2013年第5期424-425,共2页Chinese Journal of Endocrine Surgery

摘　　要：目的 探讨Galectin-3在甲状腺滤泡性肿瘤中的表达,及其鉴别诊断良、恶性甲状腺滤泡性肿瘤的价值.方法 对120例甲状腺滤泡性癌及80例甲状腺滤泡性腺瘤应用免疫组织化学方法检测Galectin-3的表达.结果 Galectin-3表达阳性率在甲状腺滤泡性癌为84％,在甲状腺滤泡性腺瘤为19％（P＜0.01）.Galectin-3表达强阳性者,在甲状腺滤泡性癌占40％,而在甲状腺滤泡性腺瘤,无一例强阳性.结论 Galectin-3表达可作为鉴别甲状腺良、恶性滤泡性肿瘤的重要参考指标.Objective To analyze the expression of Galectin-3 in thyroid follicular tumors and its clinical significance in differential diagnosis between benign and malignant thyroid follicular tumor.Methods The expression of Galectin-3 in 120 cases of thyroid follicular carcinoma and 80 cases of thyroid follicular adenoma was detected by immunohistochemical technique.Results The expression rate of Galectin-3 in thyroid follicular carcinoma was significantly higher than that in follicular adenoma（84％ vs 19％,P ＜ 0.01）.Strong positive expression of Galectin-3 was found in 40％ cases of thyroid follicular carcinoma and no case of thyroid follicular adenoma.Conclusions The expression of Galectin-3 can be regarded as an important parameter for differential diagnosis between benign and malignant thyroid follicular tumor.

关 键 词：甲状腺滤泡性肿瘤 免疫组织化学 基因表达 

分 类 号：R736.1[医药卫生—肿瘤]