儿童急性白血病患儿血清瘦素和脂联素水平及其临床意义  

Clinical study of leptin and adiponectin in childhood acute leukemia

作　　者：郁培佳[1] 张宝玺[1] 马夫天[1] 

机构地区：[1]河北医科大学第二医院儿科,050000

出　　处：《中国小儿血液与肿瘤杂志》2013年第5期234-236,共3页Journal of China Pediatric Blood and Cancer

摘　　要：目的分析儿童急性白血病患儿血清瘦素和脂联素水平并探讨其临床意义。方法采用双抗体夹心酶联免疫吸附试验技术分别检测30例儿童急性白血病患儿初诊未治前、初次缓解后、缓解后3个月和对照组30例健康儿童血清中瘦素及脂联素水平并进行比较。结果急性白血病患儿初诊未治组血清瘦素和脂联素水平均显著低于缓解组、缓解3个月组及对照组,化疗缓解后,其血清瘦素和脂联素水平逐渐上升接近正常。结论血清瘦素和脂联素可以作为急性白血病的一种检测指标,动态检测两者水平在儿童急性白血病不同治疗阶段的变化可作为判断病情发展和评估治疗效果的重要指标。Objective To investigate the serum levels of leptin and adiponectin in different phases of chemotherapy,and explore its clinical significance in childhood acute leukemia.Methods Matched samples of new diagnosis （ND）,complete remission （CR） and remission for 3 months （R-3） from 30 cases as well as 30 samples from healthy children （control） were collected.Double antibody sandwich enzyme-linked immunosorbent assay technology （ELISA） was used to detect the serum levels of leptin and adiponectin.Results The serum levels of leptin and adiponectin in ND samples were significantly lower than those in CR,R-3 and control samples.The serum levels of leptin and adiponectin increased to the normal after complete remission.Conclusions The serum levels of leptin and adiponectin could be considered as an index of childhood acute leukemia.Dynamic monitoring leptin and adiponectin in different stages of treatment was necessary for the evaluation of disease progression and therapeutic effect.

关 键 词：瘦素 脂联素 急性白血病 体块指数 儿童 

分 类 号：R733.71[医药卫生—肿瘤]