脑源性神经营养因子与脑缺血  

Brain-derived neurotrophic factor and cerebral ischemia

作　　者：李影[1] 黄永璐[1] 高宗良[1] 

机构地区：[1]安徽医科大学第二附属医院神经内科,合肥230601

出　　处：《国际脑血管病杂志》2013年第9期707-710,共4页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金（81000534）

摘　　要：脑源性神经营养因子（brain-derived neurotrophic factor,BDNF）是中枢神经系统中最普遍的神经营养因子之一.在神经系统的发育和成熟过程中,BDNF在维持神经元功能、促进神经元损伤后再生修复以及防止神经元变性等方面均发挥着重要作用.目前,很多学者正致力于BDNF治疗脑缺血的研究,并已取得了一些进展.文章对BDNF的分子生物学特征、生物学功能、在脑缺血中的作用和机制以及作为脑缺血干预靶点的可能性进行了综述.Brain-derived neurotrophic factor （BDNF） is one of the most prevalent growth factors in the central nervous system （CNS）. In the development and maturation processes of the nervous system, BDNF plays an important role in maintaining neuronal function, promoting neuronal regeneration after injury, and preventing neuronal degeneration, etc. At present, many researchers are being dedicated to the research of BDNF for treatment of brain ischemia and have achieved some progress. This article reviews the molecular biological characteristics and biological function of BDNF, roles and mechanisms in cerebral ischemia, and the possibility as an intervention target of cerebral ischemia.

关 键 词：脑缺血 脑源性神经营养因子 神经保护药 

分 类 号：R743[医药卫生—神经病学与精神病学]