膜相关性鸟苷酸激酶与脑缺血  

Membrane-associated guanylate kinases and cerebral ischemia

作　　者：李庆节[1] 徐运[1] 

机构地区：[1]南京医科大学鼓楼医院神经内科,210008

出　　处：《国际脑血管病杂志》2013年第9期711-716,共6页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金青年科学基金项目（81200897）

摘　　要：膜相关性鸟苷酸激酶（membrane associated guanylate kinase,MAGUK）是一类突触后致密蛋白（postsynaptic density,PSD）,定位于突触后膜的突触后致密区,包括PSD-95、SAP-102、PSD-93和SAP-97.MAGUK家族成员含有多个蛋白结合位点,这些特殊的结合位点负责介导多种信号的转导.MAGUK参与中枢神经系统疾病发生和发展机制,已成为神经科学研究的热点.文章简要综述了MAGUK在缺血性脑损伤中的作用.Membrane-associated guany late kinases （MAGUKs） is a class of postsynaptic density proteins （PSDs） in the postsynaptic dense of the postsynaptic membrane, including PSD-95, SAP-102, PSD-93, and SAP-97. MAGUK family members contain several protein binding sites, and these special binding sites are responsible for mediating a variety of sigaal transduction. MAGUKs participate in the occurrence and development mechanims in central nervous system diseases, and has become a topic of general interest of neuroscience. This article briefly reviews the roles of MAGUKs in ischemic brain injury.

关 键 词：脑缺血 鸟苷酸激酶 膜蛋白质类 受体 N-甲基-D-天冬氨酸 突触后密集区 

分 类 号：R743[医药卫生—神经病学与精神病学]