血管生成素2和miR-126与糖尿病大血管病变的相关性  

The relationship of angiopoietin-2 and miR-126 with diabetic macroangiopathy in type 2 diabetes

作　　者：何泉[1] 徐盈[1] 唐新华[2] 朱宝生[2] 罗海明[1] 蒋绿芝[3] 

机构地区：[1]云南省第一人民医院急诊科,昆明650032 [2]云南省第一人民医院遗传诊断中心,昆明650032 [3]昆明医科大学第二附属医院内分泌科

出　　处：《中国糖尿病杂志》2013年第11期976-979,共4页Chinese Journal of Diabetes

摘　　要：目的探讨血管生成素2(Ang-2)和miR-126与T2DM患者大血管病变的关系。方法检测241例T2DM患者和104名健康对照(NC)者的临床指标、不同时相的胰岛素及C-P水平,测定单核细胞趋化蛋白-1(MCP-1)、血管内皮舒张因子(一氧化氮,NO)、血清miR-126和Ang-2表达水平,分析Ang-2与血管内皮细胞功能、miR-126表达水平的关系。结果 T2DM合并大血管病变(T2DM+CVD)、T2DM未合并大血管病变(T2DM)组Ang-2水平与NC组比较差异有统计学意义(P<0.05)。与T2DM、NC组比较,T2DM+CVD组Ang-2水平升高,miR-126表达水平降低(P<0.05)。Ang-2与MCP-1呈正相关(r=0.456,P<0.01),与miR-126、NO呈负相关(r=-0.517,P<0.01;r=-0.327,P<0.05)。结论 Ang-2和miR-126与糖尿病大血管病变密切相关。miR-126负性调节Ang-2表达。Objective To investigate the relationship of angiopoietin-2 （Ang-2） and miR-126 with macroangiopathy in patients with T2DM.Methods Clinical indicators,the diffrent same phase of insulin and C-P levels,and monocyte chemoattractant protein-1 （MCP-1）,vascular relaxing factor （nitric oxide,NO）,miR-126 and serum Ang-2 expression levels were determined in 241 T2DM patients and 104 normal control（NC） people,the correlation between Ang-2,vascular endothelial cell function,miR-126 expression levels was analyzed.Results Ang-2 level in diabetic macroangiopathy with large vessel disease （T2DM＋CVD） group and without large vessel disease （T2DM） group was significantly higher than in NC group（P＜0.05）.Ang-2 level in T2DM＋CVD group was higer than in T2DM group,but expression of miR-126 was lower in T2DM＋ CVD group than in T2DM and NC group （P ＜ 0.05）.Expression of Ang-2 was positively related with MCP-1 （r=0.456,P＜0.01）,and negatively related with miR-126 and NO （r=-0.517,P＜0.01 ;r=-0.327,P＜0.05）.Conclusion Ang-2 is closely related to diabetic macroangiopathy.miR-126 is negatively regulate Ang-2 expression.

关 键 词：血管生成素2 MIR-126 单核细胞趋化蛋白-1 一氧化氮 大血管病变 糖尿病 2型 

分 类 号：R587.2[医药卫生—内分泌]